Oligonucleotide Scientist II — Synthesis & Scale-Up

Advanced Clinical; South San Francisco (CA); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Health coverage

Life insurance

Disability insurance

401k benefits

Job summary

Advanced Group seeks a Scientist II to support oligonucleotide discovery, synthesis, purification, characterization, and scale-up. The role collaborates across teams to advance therapeutic candidates and ensure quality with HPLC and MS analyses.

The ideal candidate has hands-on oligonucleotide chemistry experience, automation proficiency, and strong communication skills to contribute to design and strategy in a fast-paced setting.

Qualifications

• Bachelor's or Master's in Organic, Medicinal Chemistry, Chemical Biology, or related field.
• Hands-on oligonucleotide synthesis with automated synthesizers.
• Experience with nucleic acid chemistry, purification, and analytical characterization.
• Proficiency with HPLC and mass spectrometry for quality assessment.

Responsibilities

• Perform oligonucleotide synthesis, purification, and characterization for discovery programs.
• Operate and troubleshoot automated oligonucleotide synthesizers and lab equipment.
• Use HPLC and MS to assess product quality, purity, and identity.
• Support impurity profiling, process optimization, and troubleshooting.
• Contribute to experimental design, data interpretation, and scientific strategy.
• Collaborate with cross-functional teams to advance candidates.

Skills

Oligonucleotide synthesis

Automated synthesizers

HPLC

Mass spectrometry

Analytical characterization

Data interpretation

Scientific communication

Team collaboration

Education

Bachelor's degree in Organic Chemistry

Master's degree in Organic/Medicinal Chemistry or related

Tools

Automated synthesizers

HPLC systems

Mass spectrometry instruments

Job description

Advanced Group seeks a Scientist II to support oligonucleotide discovery, synthesis, purification, characterization, and scale-up. The role collaborates across teams to advance therapeutic candidates and ensure quality with HPLC and MS analyses.

The ideal candidate has hands-on oligonucleotide chemistry experience, automation proficiency, and strong communication skills to contribute to design and strategy in a fast-paced setting.