Director, Oligonucleotide Chemistry & CMC Leadership

BioSpace; Indianapolis (IN); On-site; USD 149,000 - 257,000; Full time

Benefits offered by this job

401(k) plan

Vacation benefits

Health insurance

Wellbeing benefits

Life insurance

Job summary

Lilly’s Synthetic Molecule Design and Development (SMDD) organization seeks an experienced scientist to lead CMC activities for oligonucleotide therapeutics in Indianapolis. You will guide development from lab to clinical and commercial scale, partnering with Lilly Medicine Foundry and CMOs to enable robust, scalable manufacturing.

With 5+ years in synthesis, oligonucleotides, and CMC, you will drive innovative chemistry approaches, manage regulatory interactions, and mentor a cross‑functional

Qualifications

• PhD or MS with extensive industry experience in synthesis, oligonucleotides, solid‑phase synthesis, CMC.
• Active ingredient development and associated formulated products experience preferred.
• Experience with tech transfer of processes into manufacturing.

Responsibilities

• Bring extensive oligonucleotide CMC expertise to SMDD and grow internal capability through mentoring and leadership.
• Apply modern organic and nucleic acid chemistry to develop manufacturing technologies and address CMC challenges.
• Develop impurity control strategies aligned with global regulatory expectations for clinical studies and regulatory submissions.
• Provide technical leadership across route design, process development, equipment selection, and scale‑up with internal and external partners.
• Collaborate with internal CMC networks to deliver materials and documentation for trials and submissions.

Skills

CMC expertise in oligonucleotides

Leadership & collaboration

Regulatory knowledge

Education

PhD in a relevant scientific discipline

MS in a relevant scientific discipline

Tools

Tech transfer experience

Purification technologies

Job description

Lilly’s Synthetic Molecule Design and Development (SMDD) organization seeks an experienced scientist to lead CMC activities for oligonucleotide therapeutics in Indianapolis. You will guide development from lab to clinical and commercial scale, partnering with Lilly Medicine Foundry and CMOs to enable robust, scalable manufacturing.

With 5+ years in synthesis, oligonucleotides, and CMC, you will drive innovative chemistry approaches, manage regulatory interactions, and mentor a cross‑functional