Oligonucleotide Synthesis Scientist (ASO/siRNA)

BioSpace; Indianapolis (IN); On-site; USD 66,000 - 172,000; Full time

Job summary

Lilly is seeking a collaborative chemist to join the Genetic Medicines Team in Indianapolis. The role focuses on synthesizing oligonucleotides and advancing scale-up for novel molecules in a fast-paced, interdisciplinary setting.

You will work with discovery chemistry and analysis teams, maintain equipment, and contribute to the development of lead candidates, with opportunities to influence clinical timelines and impact patient outcomes.

Qualifications

• BS/MS in Organic Chemistry, Chemistry, Biochemistry, or related discipline with 2+ years of industry experience.
• Authorized to work in the United States on a full-time basis; Lilly will not sponsor work authorization or visas for this role.

Responsibilities

• Synthesize therapeutic oligonucleotides (ASO, siRNA, and others) from 75-6000 umol scales using automated solid-phase synthesizers.
• Independently troubleshoot in the laboratory to overcome synthetic challenges and improve workflows.
• Collaborate with LGM discovery chemistry teams to understand and validate synthesis scale-up requirements for novel molecules.
• Collaborate with analytical team for analysis and characterization of processed molecules.
• Oversee and prioritize the work of scientists supporting the team.
• Support discovery and development of lead therapeutic candidates and collaborate with CMC and development teams to drive high-speed innovation towards the clinic.
• Maintain laboratory equipment and laboratory inventory/consumables for efficient operations.
• Support implementation of new technologies and workflows that accelerate innovation for LGM.

Skills

Team collaboration

Strong lab skills

Analytical skills

Technical adaptability

Documentation accuracy

Education

BS/MS in Organic Chemistry or related

Tools

AKTA OligoSynthesis

AKTA OP100

Mermade 12

AKTApure

TFF systems

Agilent LC-MS

UPLC

Orbitrap MX

HPLC

NMR

UV spectroscopy

Job description

Lilly is seeking a collaborative chemist to join the Genetic Medicines Team in Indianapolis. The role focuses on synthesizing oligonucleotides and advancing scale-up for novel molecules in a fast-paced, interdisciplinary setting.

You will work with discovery chemistry and analysis teams, maintain equipment, and contribute to the development of lead candidates, with opportunities to influence clinical timelines and impact patient outcomes.