Conjugation Scientist II, Protein Chemistry

Soufflé Therapeutics; Watertown (MA); On-site; USD 140,000 - 210,000; Full time

Job summary

Soufflé Therapeutics, a Watertown, MA biopharmaceutical company, seeks a Scientist II in Protein Science – Conjugation. You will contribute hands-on bioconjugation expertise to advance conjugation methods and molecular modalities across internal programs and collaborations. This role offers ownership from day one in a growing biotech setting.

You will lead conjugation work, develop new payload modalities, and perform rigorous analytical characterizations to support in vivo and in vitro studies.

Qualifications

• 6+ years of relevant experience (academic and industry combined).
• Hands-on experience with protein bioconjugation, particularly antibody-drug conjugates.
• Experience purifying proteins using affinity chromatography, ion exchange chromatography, and tangential flow filtration.
• Proficiency with analytical techniques: SEC-HPLC, IEX-HPLC, RP-HPLC, SDS-PAGE, MS.

Responsibilities

• Prepare novel bioconjugates for in vitro and in vivo studies.
• Lead conjugation work for internal programs and collaborations.
• Advance conjugation chemistry research into new modalities and payloads.
• Characterize conjugates using SEC-HPLC, SDS-PAGE, and mass spectrometry.
• Represent the conjugation team in cross-functional meetings.

Skills

Protein bioconjugation

Antibody-drug conjugates

Protein purification

Analytical chemistry

Mass spectrometry

Education

Ph.D. in Chemistry

BS with 10+ years' conjugation experience

Tools

SEC-HPLC

IEX-HPLC

RP-HPLC

SDS-PAGE

Mass spectrometry

Job description

Soufflé Therapeutics, a Watertown, MA biopharmaceutical company, seeks a Scientist II in Protein Science – Conjugation. You will contribute hands-on bioconjugation expertise to advance conjugation methods and molecular modalities across internal programs and collaborations. This role offers ownership from day one in a growing biotech setting.

You will lead conjugation work, develop new payload modalities, and perform rigorous analytical characterizations to support in vivo and in vitro studies.