Bioconjugation Scientist – Advanced ADC/AOC Conjugates

Dyne Therapeutics; Waltham (MA); On-site; USD 115,000 - 140,000; Full time

Job summary

Dyne Therapeutics is seeking a Scientist, Bioconjugation in Waltham, MA to design, synthesize, purify, and optimize novel bioconjugates supporting the company’s therapeutic pipeline.

The role emphasizes expert bioconjugation chemistry, protein purification, and analytical characterization, with collaboration across biology, engineering, and process development to drive discovery through development.

Qualifications

• PhD in chemistry, biochemistry, chemical biology, pharmaceutical sciences, or related field with 0–3 years of industry experience; or an MS with 8+ years.
• Hands-on experience in bioconjugation chemistry and protein purification.
• Experience with conjugation of proteins, peptides, antibodies, or oligonucleotides.
• Strong understanding of linker chemistry, conjugation mechanisms, and site-specific modification strategies.
• Hands-on purification techniques including HPLC, FPLC, SEC, ion-exchange chromatography, and affinity chromatography.
• Experience with analytical characterization methods such as LC-MS, UPLC, capillary electrophoresis, SDS-PAGE, UV-Vis spectroscopy, and dynamic light scattering.
• Knowledge of protein chemistry, oligonucleotide therapeutics, or antibody-based therapeutics.
• Ability to independently design and execute experimental work within defined research projects, applying sound scientific methodology to address increasingly complex problems.

Responsibilities

• Designs and conducts experiments to synthesize and optimize the conjugation of oligonucleotides to proteins, peptides, and antibodies.
• Develops and evaluates novel conjugation strategies, linker technologies, and site-specific modification approaches.
• Purifies and characterizes bioconjugates using chromatographic, spectroscopic, and complementary analytical techniques.
• Analyzes and interprets experimental data to guide molecular design, experimental strategy, and process optimization.
• Independently troubleshoots complex synthetic, purification, and analytical challenges.
• Collaborates with cross-functional teams to advance therapeutic candidates and achieve project milestones.
• Maintains detailed and accurate experimental records and communicates findings through technical reports, presentations, and team discussions.
• Contributes to internal technology development initiatives and bioconjugation platform innovation.
• Supports the transfer of conjugation processes to development and manufacturing teams as programs advance.
• Maintains current knowledge of emerging technologies and scientific literature in bioconjugation, protein chemistry, and oligonucleotide therapeutics.

Skills

Bioconjugation chemistry

Protein purification

Analytical characterization

Experimental design

Data interpretation

Cross-functional collaboration

Education

PhD in chemistry

MS with 8+ years experience

Tools

HPLC

FPLC

Size-exclusion chromatography

Ion-exchange chromatography

Affinity chromatography

LC-MS

Job description

Dyne Therapeutics is seeking a Scientist, Bioconjugation in Waltham, MA to design, synthesize, purify, and optimize novel bioconjugates supporting the company’s therapeutic pipeline.

The role emphasizes expert bioconjugation chemistry, protein purification, and analytical characterization, with collaboration across biology, engineering, and process development to drive discovery through development.