Associate Scientist, Protein Conjugation and Purification

Soufflé Therapeutics; Watertown (MA); On-site; USD 85,000 - 115,000; Full time

Job summary

Soufflé Therapeutics in Watertown, MA is seeking an Associate Scientist, Protein Conjugation and Purification to produce and purify protein bioconjugates for our in vitro and in vivo studies. This hands-on role focuses on developing purification strategies, validating conjugation chemistries, and delivering high-quality material for research collaborations.

The successful candidate will contribute to basic protein science workflows, operate analytical tools, and collaborate across teams to

Qualifications

• Hands-on experience with protein chemistry including FPLC, HPLC, and TFF.
• Strong troubleshooting skills.

Responsibilities

• Purify and characterize protein bioconjugates to support in vitro and in vivo studies.
• Develop and optimize methods for preparation and purification of bioconjugates.
• Generate protein bioconjugates using a range of conjugation chemistries.
• Characterize conjugates using SEC-HPLC, SDS-PAGE, and mass spectrometry.

Skills

Protein chemistry

Troubleshooting

Bioconjugation

Education

BS + 1 year experience or MS in biochemistry/biotechnology/chemistry

Tools

SEC-HPLC

SDS-PAGE

Mass spectrometry

FPLC

TFF

Job description

Soufflé Therapeutics | Associate Scientist, Protein Conjugation and Purification | Job Description

Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!

Position Summary:

As Soufflé Therapeutics grows its research pipeline – targeting more tissues and taking on more collaborations – we need hands-on support producing, purifying, and characterizing protein bioconjugates. As our new Associate Scientist, Protein Conjugation and Purification, you'll be a key contributor to that pipeline, generating and purifying material that directly supports our in vitro and in vivo studies. If you want to build your bioconjugation and purification skills in a fast-paced, high-impact environment, this is a great place to start.

Key Responsibilities

• Purify and characterize protein bioconjugates to support Soufflé's in vitro and in vivo studies
• Develop and optimize methods for the preparation and purification of bioconjugates
• Generate protein bioconjugates using a range of conjugation chemistries
• Characterize conjugates using techniques such as SEC-HPLC, SDS-PAGE, and mass spectrometry
• Present data to colleagues and coordinate efforts with other teams

What Success Looks Like

• In 3 months: You're acquainted with our basic protein science workflows, protocols, and instrumentation
• In 6 months: You're carrying out routine lab work independently, with minimal supervision
• In 12 months: You're independently troubleshooting issues and owning experimental projects with minimal oversight, with a mature understanding of how your work fits into Soufflé's broader efforts

Qualifications — Required

• Some hands-on experience with protein chemistry, including FPLC, HPLC, and TFF
• Strong troubleshooting skills

Education

• BS + 1 year of relevant experience, or a completed MS, in biochemistry, biotechnology, chemistry, or a related field

At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements.