Associate Scientist, Bioanalytical Assays

Serif Biomedicines, Inc.; Cambridge (MA); Sur place; USD 96 000 - 127 000; Plein temps

Avantages offerts par ce poste

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Résumé du poste

Serif Biomedicines, Inc. is seeking an Associate Scientist to drive bioanalytical assays for a novel DNA platform in a fast-paced biotech setting in Cambridge, MA.

You will handle in vitro and in vivo assays, bringing rigor, curiosity, and innovation to nucleic acid therapeutics development, collaborating across a multidisciplinary team. The role demands strong experience with ELISA, qPCR, ddPCR, and flow cytometry, plus tissue/cell processing skills.

Qualifications

• Masters or BS in relevant discipline with 6+ years of industry experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR.
• Hands-on experience with multi-parameter flow-cytometry, including panel design, compensation, and analysis.
• Experience with transfection methods in human and NHP PBMCs is preferred.
• Proficiency in processing tissues and isolation of various cell types from mice and NHPs.
• Prior experience in nucleic acid therapeutics or LNPs is a plus.
• Experience with histological techniques (IHC/ISH, H&E, etc.) analysis is a plus.

Responsabilités

• Execution and analysis of bioassays to assess efficacy, safety and biodistribution of nucleic acid therapeutics in rodents and NHPs.
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays to support studies in-house and at CROs.
• Communicate experimental findings in oral, written, and visual formats.
• Work independently and collaboratively in a multidisciplinary team environment.

Connaissances

Bioassays

Flow cytometry

qPCR/ddPCR

Transfection in PBMCs

Tissue isolation

IHC/ISH

Data analysis

Formation

MS/BS in relevant discipline

Outils

Flow cytometer

qPCR instruments

Description du poste

Associate Scientist, Bioanalytical Assays

Cambridge, MA

Company Summary:

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

We are searching for an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. More broadly, we are looking for an individual who enjoys working with in vitro and in vivo assays, and brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.

Key Responsibilities:

• Execution and analysis of bioassays, to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics in rodents and NHPs
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays to support studies in-house and at CROs.
• Effectively communicate experimental findings in oral, written, and visual formats.
• Work independently and collaboratively in a multidisciplinary team environment.

Qualifications:

• Masters or BS in relevant discipline with 6+ years of industry experience. Level will be based on experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR, etc.
• Hands-on experience with multi-parameter flow-cytometry, including panel design, compensation, and analysis.
• Experience with various transfection methods in human and NHP PBMCs is preferred
• Proficiency in processing tissues and isolation of various cell types (hepatocytes, immune cells etc.) from mice and NHPs
• Prior experience in nucleic acid therapeutics or LNPs is a plus
• Experience with histological techniques (IHC/IF, ISH, H&E, etc.) analysis is a plus.
• Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
• The successful candidate will be expected to demonstrate flexibility in supporting the accelerated timelines associated with data generation, analysis, and reporting for in vivo studies.
• Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Privacy Notice for Applicants:When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of your personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].

Privacy Notice for Applicants: When you apply for a role at Serif Biomedicines, Inc., a Flagship Pioneering portfolio company, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of your personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].

The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience.

Serif Biomedicines currently offers:

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.