AVP/ Head, Quantitative Pharmacology & Pharmacometrics - Oncology

Merck; West Point (PA); On-site; USD 210,000 - 320,000; Full time

Job summary

Merck seeks an experienced leader to head Quantitative Pharmacology & Pharmacometrics for oncology, directing pharmacology strategy across the pipeline using advanced analytics, modeling, and data-driven approaches to inform safety, efficacy, dosing, and regulatory decisions.

The role provides strategic leadership for the QP2 oncology organization, shapes dose and regimen strategy, mentors scientists, and represents QP2 in cross-functional governance and portfolio reviews.

Qualifications

• Ph.D. or equivalent degree in pharmaceutical sciences, pharmacometrics, statistics, or related field.
• 15+ years drug development experience with minimum 5 years in oncology
• Proven track record of model-informed drug development strategies in oncology with publications or presentations
• Experience authoring and defending regulatory filings (NDA/MAA) for multiple modalities independently
• Demonstrated expertise in population PK/PKPD analyses using standard pharmacometric software
• Comprehensive understanding of global oncology regulatory expectations and dose strategy development
• Strong team leadership, interdisciplinary collaboration, and scientific communication abilities

Responsibilities

• Provide strategic leadership and scientific oversight for QP2 oncology organization and priorities
• Shape program design, dose and regimen strategy, and regulatory interactions across pipeline
• Supervise and mentor scientists while building a modern quantitative operating model
• Lead dose optimization, exposure-response analysis, and model-informed trial design across modalities
• Represent QP2 in cross-functional teams, governance discussions, portfolio reviews, and business development

Skills

Leadership

Oncology

Regulatory filings

Pharmacometrics

PK/PKPD

Cross-functional collab

Education

Ph.D. in pharmaceutical sciences

Tools

Pharmacometric software

Job description

Merck seeks an experienced leader to head Quantitative Pharmacology & Pharmacometrics for oncology, directing pharmacology strategy across the pipeline using advanced analytics, modeling, and data-driven approaches to inform safety, efficacy, dosing, and regulatory decisions.

Responsibilities

• Provide strategic leadership and scientific oversight for QP2 oncology organization and priorities
• Shape program design, dose and regimen strategy, and regulatory interactions across pipeline
• Supervise and mentor scientists while building a modern quantitative operating model
• Lead dose optimization, exposure-response analysis, and model-informed trial design across modalities
• Represent QP2 in cross-functional teams, governance discussions, portfolio reviews, and business development

Requirements

• Ph.D. or equivalent degree in pharmaceutical sciences, pharmacometrics, statistics, or related field
• At least 15 years drug development experience with minimum 5 years in oncology industry
• Proven track record of model-informed drug development strategies in oncology with publications or presentations
• Experience authoring and defending regulatory filings (NDA/MAA) for multiple modalities independently
• Demonstrated expertise in population PK/PKPD analyses using standard pharmacometric software
• Comprehensive understanding of global oncology regulatory expectations and dose strategy development
• Strong team leadership, interdisciplinary collaboration, and scientific communication abilities