Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics – Oncology

Scorpion Therapeutics; North Wales (Montgomery County); Hybrid; USD 250,000 - 400,000; Full time

Job summary

Scorpion Therapeutics seeks a Senior Director, Group Leader in Quantitative Pharmacology and Pharmacometrics – Oncology, to provide strategic scientific leadership across oncology programs from post-preclinical to registration stages.

The role emphasizes developing MIDD strategies, overseeing a scientist team, and collaborating with Clinical Development, Translational Medicine, Biostats, and Regulatory to support regulatory submissions and translational modeling efforts. Hybrid work arrangement.

Qualifications

• Ph.D. in relevant fields with 10+ years of industry experience in oncology drug development.
• Demonstrated expertise in modeling and regulatory strategy.
• Experience leading interdisciplinary teams and authoring regulatory documents.

Responsibilities

• Develop and execute integrated MIDD strategies across oncology programs.
• Oversee a team of scientists and collaborate with cross-functional partners.
• Contribute to regulatory submissions and regulatory engagements.
• Focus on translational PK/PD, biomarker-driven dose selection, and QSP/AI/ML approaches.

Skills

MIDD

PK/PD

Biomarkers

QSP

AI/ML

Regulatory strategy

Leadership

Education

Ph.D.

Master’s/PharmD

Job description

Role:

Senior Director, Group Leader in Quantitative Pharmacology and Pharmacometrics – Oncology, providing strategic scientific leadership across oncology programs from post-preclinical to registration stages.

Responsibilities:

develop and execute integrated model-informed drug development (MIDD) strategies, oversee a team of scientists, collaborate with cross-functional partners (Clinical Development, Translational Medicine, Biostats, Regulatory), and contribute to regulatory submissions. Focus areas include translational PK/PD, biomarker-driven dose selection, and modeling approaches such as QSP and AI/ML, aligned with regulatory expectations for small molecules, biologics, ADCs, and TCEs.

Qualifications:

Ph.D. in relevant fields with ≥10 years (PhD) or ≥15 years (Master’s/PharmD) industry experience, demonstrated expertise in oncology drug development, modeling, and regulatory strategy, with experience leading interdisciplinary teams and authoring regulatory documents.

High-Value:

oncology therapeutics, model-informed development, biologics and small molecules, early to late clinical stages, cross-functional collaboration, regulatory engagement.

Work setup:

hybrid, flexible work arrangements; travel requirements not specified.