Associate Director, Biology

Ratiotx; Boston (MA); On-site; USD 175,000 - 200,000; Full time

Job summary

Ratio Therapeutics is seeking an Associate Director in Biology to lead preclinical oncology biology studies and pharmacology efforts. You will design and execute in vitro and in vivo experiments, interpret data, and communicate findings with multidisciplinary teams.

The role requires strong leadership, hands-on laboratory experience, and collaboration across chemistry, radiochemistry, clinical, and regulatory groups to drive preclinical programs forward.

Qualifications

• Ph.D. in cancer biology or related field with 10 years experience, or Master's with 15+ years in industry.
• Subject matter expertise in tumor biology and targets.
• Hands-on laboratory work to advance research objectives.
• Experience managing scientific teams in biotech/pharma settings.
• Familiarity with radioactivity or radioactive assays preferred.

Responsibilities

• Lead in vivo pharmacology studies (biodistribution, PK) in cell line and PDX models.
• Manage multiple projects with internal stakeholders, external collaborators and CROs.
• Oversee day-to-day activities of in vivo scientists.
• Collaborate with chemistry, radiochemistry, clinical and regulatory teams to advance projects.
• Contribute to regulatory submissions including IND applications.
• Ensure all biological research complies with regulatory standards.

Skills

PhD in cancer biology

In vivo pharmacology

Lab management

Team leadership

Hands-on lab work

Education

PhD in cancer biology

Master's degree with 15+ years of industry experience

Tools

Radioactivity assays

Job description

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About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About the Position

Ratio is seeking a highly motivated and experienced Associate Director in Biology to join a growing team of multidisciplinary scientists responsible for driving preclinical discovery efforts. The successful candidate will have strong interest and expertise working within preclinical oncology and pharmacology, with a well-rounded understanding of cancer biology and drug discovery techniques. The candidate will design and carry out studies to advance preclinical biology and pharmacology in vivo and in vitro and effectively communicate their data. The ideal candidate will enjoy working in a collaborative, fast-paced, multidisciplinary environment and be able to independently execute studies.

Key Responsibilities

• Lead and execute in vivo pharmacology studies (biodistribution, pharmacokinetics) in cell line and patient-derived xenografts for compound evaluation
• Manage multiple projects involving internal stake holders, external collaborators and CROs in a fast-paced collaborative environment
• Manage and oversee the day-to-day activities of a talented group of in vivo scientists
• Partner with cross-functional teams, including chemistry, radiochemistry, clinical, and regulatory, to ensure successful project progression
• Contribute to the preparation of regulatory submissions, including Investigational New Drug (IND) applications
• Ensure all biological research complies with applicable regulatory standards and guidelines
• Communicate results effectively with internal stakeholders and align on future directions
• Demonstrate experience working collaboratively within and across teams in a complex, matrix environment
• Demonstrate strong interpersonal, organizational skills and leverage team work to create innovative solutions and achieve common goals

Qualifications

• Ph.D. in cancer biology or related field with 10 years or Master's degree with 15+ years of industry experience
• Deep subject matter expertise in tumor biology surrounding current and new targets
• Proven ability and willingness to engage in hands-on laboratory work to advance research objectives
• Familiarity with or use of radioactivity or radioactive assays preferred
• Experience managing scientific teams in a biotech or pharmaceutical setting
• Excellent problem-solving skills, attention to detail, and ability to work independently with minimal supervision
• Demonstrated pursuit of quality and excellence in innovation and execution
• Integrity, respect, and compassion for colleagues, collaborators, and the patients we serve

The annual base salary for this role is expected to range between $175,000 and $200,000. This range is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. The actual base salary offered will depend on a variety of factors, including qualifications, work experience, skills, level of education attained, certifications or other professional licenses held, the location in which the applicant lives and/or from which they will be performing the job, and other job-related factors permitted by law.

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