Research Scientist, Radiopharmacology

Mariana Oncology, Inc.; Watertown (MA); Sur place; USD 81 000 - 151 000; Plein temps

Résumé du poste

Mariana Oncology, Inc. seeks an experienced Research Scientist, Radiochemistry in Watertown, MA to advance personalized medicine through radiopharmaceuticals.

You will radiolabel new product candidates, assess stability, and support in vitro/in vivo biodistribution studies within a regulated environment. You'll collaborate with Biology, Chemistry, and Pharmacology teams, analyze data, present findings, and mentor co-ops and interns while contributing to written reports and cross-functional

Qualifications

• Bachelor's degree in a scientific field with 2–5+ years of experience; MS +1+ year acceptable.
• Background in chemistry/radiochemistry.
• Interest/experience in pharmacology and/or PK research.
• Strong technical writing and oral communication abilities.
• Radiopharmaceutical experience is desired, but training available.

Responsabilités

• Perform radiolabeling, product analysis, and stability assessments.
• Collaborate with Biology, Chemistry, Pharmacology to drive studies.
• Support in vitro and in vivo radiopharmacology studies including cell binding and biodistribution.
• Follow SOPs in a regulated environment and maintain records.
• Analyze data, prepare presentations, and write reports.
• Mentor co-ops and interns; present data to teams.
• Assist with in vivo studies as needed; flexibility in duties.
• Maintain electronic lab notebook and ensure compliance with quality standards.

Connaissances

Radiochemistry background

Technical writing

Oral communication

Team collaboration

Data analysis

Formation

Bachelor's degree in a relevant scientific field

MS in a relevant scientific field +1+ year

Outils

Microsoft Office

Description du poste

Description: We are seeking an experienced Research Scientist, Radiochemistry to join Mariana's Radiopharmacology function. This role will support the development of personalized medicine and radiopharmaceuticals through a strong radiochemistry focus, working with project teams to obtain critical data to advance product development. Specifically, this laboratory-based role is responsible for radiolabeling new product candidates, addressing questions developed by the project team. These include agent stability and supporting in vitro and in vivo biodistribution studies. The candidate will also have a role in supporting broader team activities including but not limited to pharmacokinetic studies. The role requires the candidate to analyze data, make presentations at research meetings, and interface productively and successfully with internal cross-functional teams, and potentially external collaborators and contract research organizations (CROs), in addition to contributing to written reports. Illustrative Breadth of Responsibilities:

• Perform radiolabeling, product analysis, and subsequent analyses including product stability
• Work closely with other functions to identify necessary studies to drive product advancement
• Support in vitro and in vivo radiopharmacology studies by scheduling with Biology, Chemistry, and Pharmacology line functions providing radiolabeled molecules. This will include cell binding and in vitro efficacy studies, as well as in vivo biodistribution and efficacy studies
• Follow relevant SOPs, guidelines and policies in a highly regulated environment
• Accurately label samples, track collection, and maintain comprehensive records
• Follow protocols rigorously and contribute to protocol refinement when needed
• Maintain accurate and organized data entry and analysis (including maintaining the Electronic Lab Notebook in an accurate and timely fashion to ensure compliance with internal quality standards) and comply with HSE requirements
• Communicate in a time-efficient manner with cross-functional teams in a dynamic research environment
• Serve as manager for co-ops and interns; mentor junior associates
• Present data to target teams, contribute to written reports and engage with broader company teams
• Where necessary, help supporting in vivo studies as required
• Knowledge in cell culture is desired but not a requirement
• Experience working with radioactive material is desired but not a requirement – training will be provided where required
• Experience in managing CROs is desired but not required

Requirements/Skills:

• Bachelor's Degree in a relevant scientific field, plus 2 - 5+ years' experience; MS in a relevant scientific field, plus 1+ year of experience
• Background in chemistry/radiochemistry
• Interest/experience in pharmacology and/or PK research
• Strong technical writing and oral communication abilities
• Radiopharmaceutical experience is desired, but training will be provided for motivated individuals
• Ability to work with computers and software applications, such as Microsoft Office
• Ability to work in a small team setting and take on significant responsibilities during daily operations

Mariana Oncology's Values

• Building a Legacy
• Execution Excellence
• Courage of our Convictions

Mariana Oncology Compensation Summary:

The salary for this position is expected to range between $81,200 and $150,800 per year. Your compensation will also include a performance-based cash incentive.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and will be reviewed periodically upon joining Mariana Oncology. Mariana may change the published salary range based on company and market factors.