Scientist/Sr. Scientist, Radiopharma Development and Tech Transfer (Salt Lake City)

Ratio Therapeutics; West Valley City (UT); On-site; USD 130,000 - 165,000; Full time

Job summary

Ratio Therapeutics, based in Utah, is seeking a Scientist/Senior Scientist to develop GMP manufacturing processes for radiopharmaceuticals and to lead technology transfer to internal and external sites.

The candidate should have a PhD with 4+ years of relevant experience and a strong background in radiopharmaceutical production, cGMP, and regulatory writing. Salary ranges from $130,000 to $165,000 annually, with location in Salt Lake City area.

Qualifications

• PhD in life sciences with 4+ years of relevant industry/academic experience.
• Experience with radioactive materials is required.
• Proven experience in radiopharmaceutical production process development.
• Detailed working knowledge of cGMP and regulatory guidelines.
• Experience with project management and coordinating external CROs/CDMOs is a plus.
• Strong technical and regulatory writing aptitude.

Responsibilities

• Independently develop and optimize radiopharmaceutical production processes to support lead compounds.
• Lead technology transfer of early-phase production to GMP-scale methods.
• Design and execute phase-appropriate process development strategies for tech transfer and regulatory filings.
• Serve as main contact for manufacturing process transfer to internal and external sites.
• Author, review, and approve MBRs, protocols, and IND/IMPD-related documents.
• Lead manufacturing process training for personnel.
• Ensure GMP/GLP compliance and data integrity; support inspections and CAPA.

Skills

Radiopharmaceutical production

cGMP knowledge

Regulatory writing

Project management

Education

PhD in life sciences

MSc in life sciences

BSc in life sciences

Tools

Microsoft Office

Chromatography software/LIMS

Job description

About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These enabling platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About The Position

Ratio is seeking a Scientist/Senior Scientist to join our growing team of scientists. This is based either at our future Salt Lake City manufacturing site. In this role, the successful candidate will be responsible for development of GMP manufacturing processes and technology transfer to internal and external manufacturing sites. The ideal candidate has a track record of successful GMP technology development, enjoys working in a collaborative and fast-paced environment, and will seek to maintain trustworthy relationships with interdisciplinary teams at partner organizations.

Key Responsibilities

• Independently develop and optimize radiopharmaceutical production processes to support advancement of Ratio’s lead compounds.
• Lead the transition of early-phase drug product candidate production methods to processes appropriate for GMP technology transfer.
• Design and execute phase-appropriate process development strategies, including process qualification/verification/validation suitable for tech transfer and regulatory submissions.
• Serve as a main point of contact for manufacturing process technology transfer to internal and external manufacturing sites. Occasional business travel may be required (approximately 10%, Contiguous US) to facilitate technology transfer and troubleshooting activities at CDMO and internal sites.
• Author, review, and approve process related documentation (such as Master Batch records, protocols, reports and relevant sections of IND/IMPD sections and other regulatory filings).
• Lead manufacturing process training for manufacturing personnel.
• Support OOS/OOT and deviation investigations, identify root cause(s) and implement corrective and preventive actions related to manufacturing operations.
• Ensure compliance with GMP, GLP, and data integrity requirements, contributing to inspection readiness and continuous improvement of processes and workflows.

Qualifications And Requirements

• PhD in a life sciences field with 4+ years of relevant industry and/or academic experience (8+ years for MSc, 10+ years for BSc).
• Prior experience working with radioactive materials is required.
• Demonstrated experience in the development of radiopharmaceutical production processes and radiopharmaceutical manufacturing.
• Detailed working knowledge of cGMP and regulatory guidelines with a strong interest in advancing knowledge in this area.
• Experience with project management (experience managing external CROs or CDMOs is an asset).
• Proven aptitude in technical and regulatory writing.
• Ability to work effectively in a cross functional team environment and to influence without direct line-authority.
• High attention to detail and a quality and data-integrity oriented mindset.
• Open-minded and self-motivating attitude.
• Computer skills (Microsoft Office suite, chromatography software/LIMS, etc.).
• Ready and able to work in a laboratory environment.

The annual base salary for this role is expected to range between $130,000 and $165,000. This range is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. The actual base salary offered will depend on a variety of factors, including qualifications, work experience, skills, level of education attained, certifications or other professional licenses held, the location in which the applicant lives and/or from which they will be performing the job, and other job-related factors permitted by law.