Postdoctoral Fellow in Molecular Cell Biology (ref 307897)

EURAXESS Ireland; Oslo; Hybrid; NOK 550,000 - 700,000; Full time

Job summary

University of Oslo invites applications for a Recognised Researcher (R2) postdoc to investigate ER-phagy and its role in cancer progression. The project builds on image-based siRNA screens to identify regulators of ER-phagy.

The successful candidate will conduct molecular biology experiments (cell culture, CRISPR/Cas9 genome editing, protein expression and interaction analysis) and may supervise students, embracing independent and collaborative work within the project timeframe.

Qualifications

• Extensive experience in experimental lab work in molecular cell biology.
• Experience with cell culture, CRISPR/Cas9 genome editing, and protein expression.
• Ability to perform light microscopy and cancer assays.
• Experience in autophagy or intracellular trafficking is advantageous.

Responsibilities

• Investigate molecular mechanisms of ER-phagy in cancer progression.
• Perform image-based siRNA screens and related assays.
• Collaborate with the team and supervise students when applicable.

Skills

Cell culture

CRISPR/Cas9

Protein expression

Protein interaction analysis

Light microscopy

Cancer assays

Autophagy

Intracellular trafficking

Job description

Organisation/Company University of Oslo Research Field Medical sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 13 Oct 2026 - 23:00 (Europe/Oslo) Country Norway Type of Contract Temporary Job Status Full-time Hours Per Week 37.5 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Most cancer cells exhibit persistent endoplasmic reticulum stress, which promotes tumour growth, metastasis and resistance to therapies. Stressed endoplasmic reticulum is cleared by a pathway known as "ER-phagy", yet it remains unclear how ER-phagy dysregulation contributes to cancer progression. Using image-based siRNA screens, we have identified novel regulators of ER-phagy. This project aims to investigate the molecular mechanisms of ER-phagy and how this contributes to cancer progression.

The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays. Prior experience in the autophagy or intracellular trafficking fields is considered an advantage.

We are looking for a highly motivated individual with the ability to work in an accurate and structured manner to carry out the project within the given timeframe. The candidate should be able to work both independently and collaboratively, and be able to effectively interpret and communicate research results. The candidate may also have the opportunity to supervise students.