Postdoctoral Fellow in Molecular Cell Biology

Arbeidsplassen; Oslo; On-site; NOK 595,000 - 680,000; Full time

Benefits offered by this job

Welfare schemes

Exercise during working hours

Pension scheme

Career opportunities

Job summary

A postdoctoral position in the Autophagy group within the Department of Molecular Cell Biology at Oslo University Hospital and University of Oslo is available. The project CancER-phagy aims to unravel ER-phagy in cancer using image-based screens.

The successful candidate will conduct experimental work in molecular cell biology (cell culture, CRISPR/Cas9 genome editing, protein expression and interaction analysis, light microscopy) and may supervise students.

Qualifications

• PhD equivalent to Norwegian doctoral degree in cell biology or molecular biology; must have submitted thesis before application closing date.
• Fluent oral and written English.
• Strong background in molecular cell biology with experience in cell culture, genome editing, protein expression, and microscopy.
• Experience in autophagy or intracellular trafficking is an advantage.

Responsibilities

• The successful candidate will conduct experimental work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 genome editing, protein expression and interaction analysis, light microscopy and cancer assays.
• The candidate should be able to work independently and collaboratively and communicate results effectively.

Skills

Cell culture

CRISPR/Cas9

Protein expression

Interaction analysis

Light microscopy

Cancer assays

English fluency

Education

PhD equivalent to Norwegian doctoral degree in cell biology or molecular biology

Job description

Postdoctoral Fellow in Molecular Cell Biology

University of Oslo

Stillingstittel Postdoctoral Fellow in Molecular Cell Biology

A postdoctoral position is available in the Autophagy group at the Department of Molecular Cell Biology, Institute of Cancer Research, Oslo University Hospital. The position is also affiliated with the Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, University of Oslo.

The position is funded by the Research Council of Norway to work on the project “CancER-phagy - Unravelling and targeting ER-phagy in cancer”.

The proposed starting date is 01.01.2027, and the position is for a period of 3 years.

Most cancer cells exhibit persistent endoplasmic reticulum stress, which promotes tumour growth, metastasis and resistance to therapies. Stressed endoplasmic reticulum is cleared by a pathway known as “ER-phagy”, yet it remains unclear how ER-phagy dysregulation contributes to cancer progression. Using image-based siRNA screens, we have identified novel regulators of ER-phagy. This project aims to investigate the molecular mechanisms of ER-phagy and how this contributes to cancer progression.

The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays. Prior experience in the autophagy or intracellular trafficking fields is considered an advantage.

We are looking for a highly motivated individual with the ability to work in an accurate and structured manner to carry out the project within the given timeframe. The candidate should be able to work both independently and collaboratively, and be able to effectively interpret and communicate research results. The candidate may also have the opportunity to supervise students.

About the position

A postdoctoral position is available in the Autophagy group at the Department of Molecular Cell Biology, Institute of Cancer Research, Oslo University Hospital. The position is also affiliated with the Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, University of Oslo.

The position is funded by the Research Council of Norway to work on the project “CancER-phagy - Unravelling and targeting ER-phagy in cancer”.

The proposed starting date is 01.01.2027, and the position is for a period of 3 years.

Project description

Most cancer cells exhibit persistent endoplasmic reticulum stress, which promotes tumour growth, metastasis and resistance to therapies. Stressed endoplasmic reticulum is cleared by a pathway known as “ER-phagy”, yet it remains unclear how ER-phagy dysregulation contributes to cancer progression. Using image-based siRNA screens, we have identified novel regulators of ER-phagy. This project aims to investigate the molecular mechanisms of ER-phagy and how this contributes to cancer progression.

The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays. Prior experience in the autophagy or intracellular trafficking fields is considered an advantage.

We are looking for a highly motivated individual with the ability to work in an accurate and structured manner to carry out the project within the given timeframe. The candidate should be able to work both independently and collaboratively, and be able to effectively interpret and communicate research results. The candidate may also have the opportunity to supervise students.

Qualification requirements

• Candidates must have a PhD equivalent to a Norwegian doctoral degree in cell biology, molecular biology or equal. Successful candidates must have submitted their doctoral thesis prior to the application closing date.
• Fluent oral and written communication skills in English.
• Strong background in molecular cell biology.
• Experience with cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays.

Preferred skills

• Background in autophagy or intracellular trafficking field is an advantage.

Personal skills

• Highly motivated and dedicated.
• Ability to work in an accurate and structured manner.
• Ability to work independently and collaboratively.
• Ability to critically assess and interpret research results.
• Proficient communication and presentation skills.

We need different perspectives in our work

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no.

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.
More information about gender equality initiatives at UiO can be found here.

We offer

• Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development.
• A pleasant and stimulating work environment
• Good welfare schemes.
• Opportunity of up to 1.5 hours a week of exercise during working hours.
• A workplace with good development and career opportunities.
• Membership in the Statens Pensjonskasse , which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
• Salary in position as Postdoctoral Fellow, position code 1352 in salary range NOK from 595 000to 680 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.

Read more about the benefits of working in the public sector at Employer Portal.

Application

Your application should include:

• Application letter
• CV
• A complete list of publications
• Project description
• Transcripts and certificates
• Contact information for 2-3 references

General information

As the deadline applies equally to all applicants, this policy ensures equal treatment throughout the recruitment process.

The best qualified candidates will invited for interviews.

No one can be employed for more than one fixed-term period as a Postdoctoral Fellow at the same institution.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us.

The University of Oslo has a transfer agreement with all employees to secure the rights to all research results and related intellectual property.

Thoril Kristiansen (questions regarding the online application form)

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 26 500students and 7 200employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 900 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.