Postdoctoral Fellow in Molecular Cell Biology

Thoril Kristiansen (questions regarding the online application form); Oslo; On-site; NOK 595,000 - 680,000; Full time

Benefits offered by this job

Good welfare schemes

Exercise time (up to 1.5 hours/week)

Career opportunities

Pension scheme: Statens Pensjonskasse

Job summary

The Autophagy group at the Department of Molecular Cell Biology, Oslo University Hospital, offers a three-year postdoctoral position funded by the Research Council of Norway. The position is affiliated with the Centre for Cancer Cell Reprogramming (CanCell), University of Oslo.

The project, CancER-phagy, investigates ER-phagy in cancer using image-based screens. The successful candidate will work with molecular cell biology techniques, cell culture, CRISPR/Cas9, protein expression, and

Qualifications

• PhD equivalent to a Norwegian doctoral degree in cell biology or molecular biology.
• Fluent oral and written English communication.
• Strong background in molecular cell biology and related techniques.
• Experience with cell culture, CRISPR/Cas9 genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays.

Responsibilities

• Carry out experimental laboratory work in molecular cell biology.
• Apply CRISPR/Cas9 genome editing, protein expression, and microscopy techniques as part of the CancER-phagy project.
• Interpret and communicate research results, work independently and collaboratively, and potentially supervise students.

Skills

Molecular cell biology

Cell culture

CRISPR/Cas9 genome editing

Protein expression

Protein interaction analysis

Light microscopy

Cancer assays

English communication

Education

PhD in cell biology or molecular biology

Job description

About the position

A postdoctoral position is available in the Autophagy group at the Department of Molecular Cell Biology, Institute of Cancer Research, Oslo University Hospital. The position is also affiliated with the Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, University of Oslo.

The position is funded by the Research Council of Norway to work on the project "CancER-phagy - Unravelling and targeting ER-phagy in cancer".

The proposed starting date is 01.01.2027, and the position is for a period of 3 years.

Project description

Most cancer cells exhibit persistent endoplasmic reticulum stress, which promotes tumour growth, metastasis and resistance to therapies. Stressed endoplasmic reticulum is cleared by a pathway known as "ER-phagy", yet it remains unclear how ER-phagy dysregulation contributes to cancer progression. Using image-based siRNA screens, we have identified novel regulators of ER-phagy. This project aims to investigate the molecular mechanisms of ER-phagy and how this contributes to cancer progression.

The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays. Prior experience in the autophagy or intracellular trafficking fields is considered an advantage.

We are looking for a highly motivated individual with the ability to work in an accurate and structured manner to carry out the project within the given timeframe. The candidate should be able to work both independently and collaboratively, and be able to effectively interpret and communicate research results. The candidate may also have the opportunity to supervise students.

Qualification requirements

• Candidates must have a PhD equivalent to a Norwegian doctoral degree in cell biology, molecular biology or equal. Successful candidates must have submitted their doctoral thesis prior to the application closing date.
• Fluent oral and written communication skills in English.
• Strong background in molecular cell biology.
• Experience with cell culture, CRISPR/Cas9 based genome editing, protein expression and interaction analysis, light microscopy and/or cancer assays.

Preferred skills

• Background in autophagy or intracellular trafficking field is an advantage.

Personal skills

• Highly motivated and dedicated.
• Ability to work in an accurate and structured manner.
• Ability to work independently and collaboratively.
• Ability to critically assess and interpret research results.
• Proficient communication and presentation skills.

Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.

We need different perspectives in our work

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no .

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports. More information about gender equality initiatives at UiO can be found here.

We offer

• Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development.
• A pleasant and stimulating work environment
• Good welfare schemes.
• Opportunity of up to 1.5 hours a week of exercise during working hours.
• A workplace with good development and career opportunities.
• Membership in the Statens Pensjonskasse , which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
• Salary in position as Postdoctoral Fellow, position code 1352 in salary range NOK from 595 000to 680 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.