Research Associate-IV

Apitoria Pharma; Hyderabad; On-site; INR 800,000 - 1,400,000; Full time

Job summary

Apitoria Pharma in Hyderabad seeks a Process/Kilo Lab chemist to design, develop, and optimize scalable, safe synthetic routes for complex molecules. The role emphasizes translating bench-scale methods to kilo-lab scale while maintaining yield and purity.

You will work with AR&D and QC teams, analyze CPPs, and document data in ELNs and batch records. Strong emphasis on safety and environmental considerations in scale-up operations.

Qualifications

• Education: M.Sc. in Organic Chemistry.

Responsibilities

• Design, develop, and optimize robust, safe, cost-effective synthetic routes for target molecules and chiral intermediates.

Skills

Multi-step synthesis

Scale-up

Safety assessments

Analytical tools

Kilo-Lab operations

Education

M.Sc. in Organic Chemistry

Tools

NMR

HPLC

GC

LCMS

KF

Job description

Job Description for Process/Kilo Lab chemists

• Design, develop, and optimize robust, safe, cost-effective, and environmentally friendly synthetic routes for Target molecules and chiral intermediates.
• Evaluate reaction parameters (temperature, stoichiometry, addition rate, order of addition, work-up, and crystallization) to improve yield, purity, and operational cycle times.
• Perform impurity profiling, isolation, and characterization of process-related impurities and degradation products.

Translate bench-scale (gram-level) procedures to Kilo-Lab scale (multi-gram to kilogram batches).

Operate glass-lined reactors, hydrogenation units, rotary evaporators, and filtration assemblies in the Kilo-Lab environment.

• Support or lead technical transfer of processes from the laboratory to pilot plant or commercial manufacturing sites.
• Monitor critical process parameters (CPPs) and record batch data accurately in Electronic Lab Notebooks (ELNs) and batch production records
• Perform or coordinate in-process analytical testing using techniques such as HPLC, GC, NMR, TLC, LC-MS, and Karl Fischer (KF).
• Troubleshoot chemical reactions, equipment malfunctions, or yield drops during scale-up runs.
• Collaborate closely with Analytical Research and Development (AR&D) and Quality Control (QC) teams.

Required Qualifications & Skills

Education: M.Sc. in Organic Chemistry

Experience:

• 2 8 years of hands-on experience in synthetic organic chemistry, process R&D, or Kilo-Lab/pilot plant operations.

Technical Skills:

• Strong foundation in multi-step organic synthesis and reaction mechanisms.
• Proven experience in scale-up from bench scale to multi-kilogram Kilo-Lab batches.
• Familiarity with safety assessments
• Proficiency with analytical tools (NMR, HPLC, GC, LCMS) to interpret data independently