Synthetic Chemist

Topia Life Sciences; Ahmedabad District; On-site; INR 1,200,000 - 2,000,000; Full time

Job summary

Topia Life Sciences is seeking a highly motivated Synthetic Chemist to join the Synthesis Department. The role involves synthesis, purification, characterization, and scale-up of novel compounds, intermediates, and APIs, with emphasis on organic chemistry, name reactions, analytical interpretation, and meticulous lab documentation.

The candidate should hold a Ph.D. in Chemistry or M.Sc./Applied Chemistry or M.Pharm.

Qualifications

• Ph.D. in Chemistry or M.Sc./M.Pharm. with strong synthetic chemistry background.
• Experience in multi-step organic synthesis, purification, and scale-up.
• Proficient in interpreting analytical data (LC-MS, NMR, IR) and documenting procedures.

Responsibilities

• Execute multi-step organic synthesis of intermediates, impurities, novel compounds, and APIs.
• Perform reaction screening, process optimization, and scale-up activities.
• Carry out purification using column chromatography, recrystallization, and related methods.
• Design and execute synthetic routes based on literature and project needs.
• Conduct literature searches to support route scouting and troubleshooting.
• Interpret LC-MS, NMR, IR data and other analytical results.
• Maintain accurate documentation of experiments, observations, and results.
• Prepare batch records, SOPs, and project documentation.

Skills

Organic synthesis

Name reactions

Scale-up activities

Analytical data interpretation

Laboratory documentation

Experimental design

MS Office / electronic docs

Communication & teamwork

Education

Ph.D. in Chemistry

M.Sc. in Chemistry / Applied Chemistry

M.Pharm.

Job description

Job Summary

We are seeking a highly motivated and skilled Synthetic Chemist to join our Synthesis Department. The incumbent will be responsible for the synthesis, purification, characterization, and scale-up of novel compounds, intermediates, and APIs. The role requires strong knowledge of organic chemistry, name reactions, analytical data interpretation, and laboratory documentation practices.

Key Responsibilities

• Execute multi-step organic synthesis of intermediates, impurities, novel compounds, and APIs.
• Perform reaction screening, process optimization, and scale-up activities.
• Carry out compound purification using column chromatography, recrystallization, and other purification techniques.
• Design and execute synthetic routes based on literature and project requirements.
• Conduct literature searches to support route scouting, process development, and troubleshooting.
• Interpret analytical data including LC-MS, NMR, IR, and other spectroscopic techniques.
• Ensure accurate and timely documentation of experimental procedures, observations, and results.
• Prepare technical reports, batch records, SOPs, and project documentation.
• Analyze critical reaction parameters and identify opportunities for process improvement.
• Adhere to laboratory safety, quality, and compliance requirements.
• Collaborate with cross-functional teams for project execution and successful delivery.

Educational Qualification

• Ph.D. in Chemistry OR
• M.Sc. in Chemistry / Applied Chemistry OR
• M.Pharm.

Mandatory Skills

• Organic Synthesis and General Chemistry
• Column Chromatography
• Name Reactions and Reaction Mechanisms
• Scale-up Activities
• Scientific Documentation
• Computer Proficiency (MS Office, Electronic Documentation Systems)
• Experimental Design and Troubleshooting

Preferred / Desirable Skills

• Development of Unknown Compounds
• API Synthesis and Process Development
• Literature Search and Patent Review
• Process Optimization
• Column Chromatography Techniques
• Technical Report Writing
• Impurity Synthesis and Characterization

Technical Competencies

• LC-MS (Liquid Chromatography-Mass Spectrometry)
• NMR Spectral Interpretation
• IR Spectroscopy Interpretation
• Analytical Data Evaluation
• Critical Condition/Reaction Parameter Analysis
• Purification and Characterization Techniques
• Laboratory Documentation and Compliance

Experience

• Executive: 13 years
• Sr. Executive: 3–6 years
• Scientist: 6+ years

Key Attributes

• Strong analytical and problem-solving skills
• Attention to detail and data integrity
• Ability to work independently and within project timelines
• Good communication and teamwork skills
• Strong scientific aptitude and innovation mindset