Senior Bioinformatician - In-silico Protein Design

T Cypher Bio; Oxford; On-site; GBP 50,000 - 80,000; Full time

Job summary

An innovative biotechnology company is seeking a Senior Bioinformatician to join their Computational Biology team. This role focuses on applying computational methods and machine learning to enhance protein engineering for TCR-based therapeutics. The ideal candidate will have a strong background in bioinformatics, with experience in developing ML models and bioinformatics pipelines. This is an exciting opportunity to contribute to impactful research and development in a fast-paced environment, where your skills will directly influence the advancement of novel therapeutics aimed at improving patient outcomes.

Benefits

Competitive salary

Training and development opportunities

Modern office and laboratory facilities

Impactful work in biotech

Qualifications

• 3+ years of industry experience in bioinformatics or protein engineering.
• Strong Python skills and experience with ML techniques.

Responsibilities

• Drive innovation in computational techniques for protein engineering.
• Develop and deploy bioinformatics pipelines and ML models.

Skills

Bioinformatics

Machine Learning

Python

Protein Engineering

Data Analysis

Education

BSc in Bioinformatics

MSc in Bioinformatics

PhD in Bioinformatics

Tools

Version Control Systems

Bioinformatics Pipelines

Job description

Senior Bioinformatician - In-silico protein design

T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior Bioinformatician with a strong background in protein engineering to advance our biologics platform as part of the Computational Biology team.

What you will do

This role will involve driving bioinformatics and ML-based efforts to engineer bispecific immune cell engagers towards our clinical programmes. The ideal candidate would have a strong background and interest in applying computational methods towards protein engineering, ideally including developability assessment. The role will involve exploratory bioinformatics, deploying ML-based approaches, and developing pipelines to expand on and enhance our analysis & data infrastructure.

Key Responsibilities

• Drive innovation in the application of computational techniques to protein engineering of clinical molecules

• Guide data generation to support development of new computational techniques and ML models

• Train and deploy ML approaches for improving protein engineering processes

• Develop and deploy tools and metrics for assessment of molecule developability

• Develop and integrate bioinformatics pipelines with our analysis & data infrastructure

• Regularly communicate findings and developments with the Research team and management

• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects

• Maintain and implement good code, version control, and organisation of data

To be successful you will need

• Appropriate qualifications / experience in bioinformatics, one of:
  • Relevant BSc with 3+ years relevant industry experience
  • Relevant MSc with 2+ years relevant industry experience
  • Relevant PhD

• Demonstrated experience and strong interest in utilising computational techniques within protein engineering

• Experience with at least applying ML techniques to protein engineering, ideally developing and training ML models in the area

• Strong Python skills and knowledge of general software development techniques and standards

• Ideally, some experience of developability assessment in drug development

• Passionate about bioinformatics, coding, and the biological applications of computational techniques

• Desire to develop clinical TCR-based therapeutic molecules

• Ability to adapt to multiple roles in an evolving company

• Enjoy working towards challenging goals in a fast-moving environment

• Strong organizational and communication skills (both written and verbal)

• Strong drive to deliver on company milestones and goals

What we offer

Competitive salary and benefits commensurate with qualifications and experience.

Modern, well-equipped office and laboratory facilities on Oxford Science Park.

Training and development opportunities in-line with the company's goals and growth plans.

An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients' lives.

How to apply

Applications will be evaluated in the order that they are received, you are encouraged to apply as soon as possible.

Applications will close once the position is filled.