Protein Purification & Biochemistry Scientist – Cambridge

Talentmark; Cambridge; On-site; GBP 35,000 - 52,000; Full time

Job summary

Talentmark is recruiting a Scientist – Protein Purification and Biochemistry to join a biotech start-up in Cambridge. The position is permanent with Mon-Fri daytime hours, based at the Cambridge site.

You will contribute to drug discovery by applying protein purification and biochemical characterization to support construct design, protein production and downstream analyses. Experience with AKTA systems and antibody-related workflows is advantageous.

Qualifications

• A minimum of a BSc Degree in Biochemistry, Molecular Biology, or related discipline.
• Hands-on experience with protein purification techniques (Protein A, affinity chromatography, SEC).
• Hands-on experience operating and troubleshooting ÄKTA chromatography systems.
• Experience working with matrices such as cell lysates and human serum.
• Understanding of analytical techniques (SEC, SDS-PAGE, charge-based assays, mass spectrometry) applied to therapeutic proteins.
• Awareness of therapeutic antibody development considerations.

Responsibilities

• Independently plan, execute and troubleshoot protein purification workflows, including affinity chromatography, Protein A and size-exclusion chromatography.
• Coordinate recombinant protein expression and purification activities in-house and with CRO partners, ensuring material is suitable for downstream assays.
• Establish, optimise and transfer protein purification methods from external partners where required.
• Develop practical approaches to overcome protein production and purification challenges and proactively identify potential risks or blockers.
• Analyse and interpret purification and biochemical data to support project decisions and recommend next steps.
• Work with CROs and other external partners to support protein delivery, monitor progress and ensure agreed technical requirements are met.
• Support the evaluation of outsourcing partners where additional external capability is required.

Skills

Protein purification

Biochemistry

AKTA chromatography

Protein A

SEC

SDS-PAGE

Mass spectrometry

SPR

ELISA

Education

BSc Degree in Biochemistry, Molecular Biology, or related discipline

Tools

ÄKTA chromatography systems

Job description

Talentmark is recruiting a Scientist – Protein Purification and Biochemistry to join a biotech start-up in Cambridge. The position is permanent with Mon-Fri daytime hours, based at the Cambridge site.

You will contribute to drug discovery by applying protein purification and biochemical characterization to support construct design, protein production and downstream analyses. Experience with AKTA systems and antibody-related workflows is advantageous.