Protein Production Scientist - Biologics (London)

Substrate Bio Ltd; Greater London; On-site; GBP 65,000 - 90,000; Full time

Benefits offered by this job

30 days annual leave

Pension with 10% employer contribution

Private health cover

Job summary

Substrate Bio Ltd. is seeking a Scientist/Senior Scientist to advance bench-level protein science in our London lab. You will design and run DNA-based workflows, express and purify proteins, and perform QC with an eye toward automation readiness and data integrity.

The role emphasizes hands-on work at the bench in early phases, while collaborating with automation engineers and software teams to transition tasks to automated platforms. Evidence of SOP authoring will be valued.

Qualifications

• PhD in protein biochemistry, molecular biology, biophysics, analytical characterisation, or biologics developability with 2+ years hands-on experience; or MSc with 5+ years bench experience.
• Hands-on competence across protein science: molecular biology, protein expression, purification, and QC, including high-throughput platforms.
• Fluency with structured experimental data capture and proficiency with a LIMS/ELN.
• Experience collaborating with automation, software, and AI colleagues on closed-loop workflows.
• Ability to author SOPs and grow into protocol ownership within 12 months.

Responsibilities

• Design, run, and validate bench protocols for DNA production, protein expression, purification, and QC.
• Collaborate with automation and software teams to align manual workflows with automation-ready processes.
• Contribute to SOPs and protocol documentation as the lab scale increases.

Skills

DNA design

Linear DNA production

Protein expression

Protein purification

Quality control (QC)

Hands-on bench work

Automation readiness

Data analysis

Education

PhD in protein biochemistry / molecular biology / biophysics

MSc with 5+ years bench experience in protein science

Tools

Gibson Assembly

Golden Gate assembly

LIMS/ELN or similar data infrastructure

Cell-free / IVTT expression systems

Job description

Substrate Bio Ltd. is seeking a Scientist/Senior Scientist to advance bench-level protein science in our London lab. You will design and run DNA-based workflows, express and purify proteins, and perform QC with an eye toward automation readiness and data integrity.

The role emphasizes hands-on work at the bench in early phases, while collaborating with automation engineers and software teams to transition tasks to automated platforms. Evidence of SOP authoring will be valued.