Method Development Lead

Nexus Life Sciences; Greater London; Sur place; GBP 54 000 - 66 000; Plein temps

Avantages offerts par ce poste

Leadership development

Résumé du poste

Nexus Life Sciences in the United Kingdom seeks an experienced MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise with team leadership to ensure robust analytical methodologies.

The candidate will lead method development, optimize extraction and chromatography, mentor the team, and ensure GLP/SOP compliance.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.

Responsabilités

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumable spend.
• Write and approve Methods of Analysis and transfer validated methods to analytical teams.
• Support regulatory submissions and respond to regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review, and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Connaissances

GxP laboratory experience

Leadership / management

HPLC/UPLC/LCMSMS

Chromatography data systems

Problem solving

Regulatory & GLP knowledge

Communication & organization

Formation

Biochemistry / Biomedical Science degree

Outils

Empower

MassLynx

Minitab

Description du poste

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.