Method Development Lead

Nexus Life Sciences; Wolverhampton; Presencial; GBP 36 000 - 60 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Leadership opportunity

Professional development

Collaborative work culture

Cutting-edge lab environment

Resumo da oferta

Nexus Life Sciences seeks an MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards in a leading-edge laboratory in Wolverhampton, UK. The role combines deep technical work with team leadership and regulatory support.

The candidate will optimise extraction and chromatography methods, oversee a skilled Method Development & Validation team, and ensure GLP/SOP compliance while contributing to regulatory submissions and continuous improvement

Qualificações

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
• Proficiency in method development, optimisation and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and liquid-liquid extraction.
• Understanding of regulatory and GLP requirements.

Responsabilidades

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP, SOPs and international guidelines compliance.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumables spend.
• Write and approve Methods of Analysis and transfer validated methods.
• Support regulatory submissions and respond to regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Conhecimentos

GxP laboratory

Leadership

HPLC/UPLC

LCMSMS

Method development

Validation

Sample extraction

Regulatory knowledge

Data systems

Formação académica

Biochemistry degree

Ferramentas

Empower

MassLynx

DOE

Minitab

Descrição da oferta de emprego

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.