Method Development Lead

Nexus Life Sciences; Guildford; On-site; GBP 36,000 - 60,000; Full time

Benefits offered by this job

Leadership role

Training opportunities

Collaborative culture

Innovative projects

Job summary

Nexus Life Sciences in Guildford seeks a skilled MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP. This role blends technical leadership with team management to ensure GLP compliance across projects.

You will optimise extraction and chromatography, mentor a dedicated team, and contribute to regulatory submissions while upholding SOPs and continuous improvement initiatives.

Qualifications

• 4+ years in a GxP laboratory with management experience.
• Experience with HPLC/UPLC/LCMSMS and chromatography data systems.
• Strong capability in method development, optimisation and validation.

Responsibilities

• Lead method development and validation as SME.
• Optimise extraction techniques, chromatography methods and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP and SOP compliance; follow international guidelines.
• Troubleshoot analytical methods and implement improvements.
• Oversee cost-effective lab operations and consumables spend.
• Write and approve Methods of Analysis and transfer validated methods to teams.
• Support regulatory submissions and respond to regulatory queries.
• Conduct investigations, implement CAPAs and drive continuous improvement.
• Prepare and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

method development

validation

GxP knowledge

troubleshooting

communication

leadership

Education

Degree in Biochemistry/Biomedical Science or related field

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.