Method Development Lead

Nexus Life Sciences; Slough; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Career development

Competitive salary

Collaborative lab culture

Job summary

Nexus Life Sciences, based in Slough, seeks a highly skilled MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards. This role blends technical leadership with people management to ensure compliant, robust methods.

You will oversee method development, optimization of extraction and chromatography, and mentor the M&D team. Strong GLP knowledge and regulatory interaction are essential, with opportunities for professional growth.

Qualifications

• Requires a degree in Biochemistry, Biomedical Science, or a related field.
• Minimum 4+ years in a GxP laboratory with 2+ years in management.
• Expertise in HPLC/UPLC/LCMSMS and chromatography data systems.

Responsibilities

• Lead method development and validation as SME.
• Optimise extraction techniques, chromatography methods, and LC columns.
• Mentor and manage the Method Development & Validation team.

Skills

HPLC/UPLC

LCMSMS

Method development

GxP/GLP compliance

Leadership

Troubleshooting

Education

Bachelor's degree in Biochemistry, Biomedical Science, or related field

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.