Method Development Lead

Nexus Life Sciences; Sheffield; Presencial; GBP 54.000 - 66.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Leadership opportunity

Professional development

Collaborative culture

Innovative bioanalytical projects

Descripción de la vacante

Nexus Life Sciences in the United Kingdom is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise and strong team leadership.

You will optimise extraction and chromatography, mentor the Method Development & Validation team, ensure GLP compliance, support regulatory submissions, and drive continuous improvement across the laboratory.

Formación

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Responsabilidades

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumable spend.
• Write and approve Methods of Analysis and transfer validated methods to analytical teams.
• Support regulatory submissions and resolve regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review, and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Conocimientos

HPLC

UPLC

LCMSMS

Chromatography

Method development

Validation

Troubleshooting

GLP

Communication

Leadership

Educación

Biochemistry or related

Herramientas

Empower

MassLynx

Minitab

Descripción del empleo

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.