Method Development Lead

Nexus Life Sciences; Birmingham; On-site; GBP 50,000 - 60,000; Full time

Benefits offered by this job

Leadership opportunity

Professional development

Collaborative culture

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role blends technical expertise with leadership to guide the Method Development & Validation team in a cutting-edge lab in Birmingham.

The successful candidate will optimise LC methods, oversee GLP compliance, support regulatory submissions, and mentor staff to foster continuous improvement in a fast-paced bioscience environment.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.
• Expertise in HPLC/UPLC, LCMSMS, and chromatography data systems.
• Strong problem-solving and troubleshooting abilities.
• Knowledge of protein precipitation, SPE, and liquid-liquid extraction techniques.
• Understanding of regulatory and GLP requirements.

Responsibilities

• Lead method development and validation as SME.
• Optimise extraction, chromatography, and LC columns.
• Mentor Method Development & Validation team.
• Ensure GLP, SOPs, and guidelines compliance.
• Troubleshoot methods and implement improvements.
• Manage lab spend and cost-effective operations.
• Prepare and transfer validated methods to teams.
• Support regulatory submissions and answer queries.
• Drive CAPAs and continuous improvement.
• Lead team meetings and staff development.

Skills

Leadership

Problem-solving

Communication

Regulatory knowledge

Troubleshooting

Analytical chemistry

Education

Degree in Biochemistry/ Biomedical Science or related field

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.