Method Development Lead

Nexus Life Sciences; Nottingham; On-site; GBP 54,000 - 66,000; Full time

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead in Nottingham to drive LCMSMS bioanalytical method development and validation under GxP standards.

The role combines technical expertise with team leadership, overseeing a M&D & Validation group and ensuring GLP/SOP compliance. You will mentor staff, support regulatory submissions, and drive continuous improvement across the lab.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Mentoring the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumables.
• Write and approve Methods of Analysis and transfer validated methods.
• Support regulatory submissions and resolve regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Chromatography data systems

Method development

Validation

Protein precipitation

SPE

Liquid-Liquid extraction

GLP

Regulatory compliance

Communication

Leadership

Education

Biochemistry or Biomedical Science degree

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.