Method Development Lead

Nexus Life Sciences; Stevenage; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Leadership opportunity

Professional development

Collaborative culture

Innovative projects

Job summary

Nexus Life Sciences is seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. You will lead a team of scientists, ensure GLP SOP adherence, and contribute to regulatory submissions.

The role combines technical leadership with people management, overseeing method development, troubleshooting, and regulatory support. A strong background in HPLC/UPLC/LCMSMS and DOE is required.

Qualifications

• Must have a degree in Biochemistry, Biomedical Science, or a related field.
• Minimum 4+ years in a GxP laboratory with at least 2+ years in management.
• Expertise in HPLC/UPLC/LCMSMS and chromatography data systems.
• Strong problem-solving, troubleshooting, and leadership abilities.
• Familiarity with protein precipitation, SPE, and liquid–liquid extraction in sample prep.
• Understanding of GLP, SOPs, and regulatory requirements.
• Excellent communication and organizational skills.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimize extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP compliance, SOP adherence, and international guidelines.
• Troubleshoot analytical methods and implement improvements.
• Oversee cost-effective lab operations and consumables spend.
• Write and approve Methods of Analysis and transfer methods to teams.
• Support regulatory submissions and respond to queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review, and ensure GLP SOP adherence.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Method development

Validation

Leadership

Communication

Regulatory knowledge

Problem solving

DOE

Minitab

MassLynx

Empower

Education

Biochemistry / Biomedical Science degree

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.