PhD Candidate: Gene Regulation & Genome Architecture

Inserm France; Illkirch-Graffenstaden; Hybride; EUR 20 000 - 27 000; Plein temps

Résumé du poste

Inserm France at IGBMC invites applications for a PhD project focused on the transcription factor SALL4 in embryonic stem cells. You will apply state-of-the-art genomics, CRISPR/Cas9 engineering, and transcriptome analyses to uncover how transcription is regulated during early development.

This is a collaborative, international environment with access to genomics, proteomics, microscopy, and bioinformatics facilities, aiming to clarify how SALL4 controls cell identity and its role in

Qualifications

• Recently obtained Master degree in genomics, molecular biology or other relevant discipline.
• Strong motivation to work in the field of gene regulation and chromatin biology.
• Good handling of standard molecular biology techniques.
• Prior experience in generating or analysing genomics data would be desirable, but not mandatory.
• English language proficiency (B2 or higher).

Responsabilités

• In this PhD project, you will exploit state-of-the-art genomics techniques to dissect the molecular function of the transcription factor SALL4 in embryonic stem cells: regulation of transcription via long range enhancer-promoter looping and regulation of 3D genome structure via lamina-associated domains.
• These investigations will help us understand how SALL4 controls embryonic development and how this protein is de-regulated in developmental disorders and aggressive cancers.
• You will join a collaborative, international group with access to genomics, bioinformatics, proteomics, microscopy and cell culture facilities.

Connaissances

English (B2)

Genomics literacy

Formation

Master degree in genomics / molecular biology

Outils

CRISPR/Cas9 engineering

Description du poste

Inserm France at IGBMC invites applications for a PhD project focused on the transcription factor SALL4 in embryonic stem cells. You will apply state-of-the-art genomics, CRISPR/Cas9 engineering, and transcriptome analyses to uncover how transcription is regulated during early development.

This is a collaborative, international environment with access to genomics, proteomics, microscopy, and bioinformatics facilities, aiming to clarify how SALL4 controls cell identity and its role in