DOCTORANT_052_RP - H/F

Inserm France; Illkirch-Graffenstaden; Hybrid; EUR 20,000 - 27,000; Full time

Job summary

Inserm France at IGBMC invites applications for a PhD project focused on the transcription factor SALL4 in embryonic stem cells. You will apply state-of-the-art genomics, CRISPR/Cas9 engineering, and transcriptome analyses to uncover how transcription is regulated during early development.

This is a collaborative, international environment with access to genomics, proteomics, microscopy, and bioinformatics facilities, aiming to clarify how SALL4 controls cell identity and its role in

Qualifications

• Recently obtained Master degree in genomics, molecular biology or other relevant discipline.
• Strong motivation to work in the field of gene regulation and chromatin biology.
• Good handling of standard molecular biology techniques.
• Prior experience in generating or analysing genomics data would be desirable, but not mandatory.
• English language proficiency (B2 or higher).

Responsibilities

• In this PhD project, you will exploit state-of-the-art genomics techniques to dissect the molecular function of the transcription factor SALL4 in embryonic stem cells: regulation of transcription via long range enhancer-promoter looping and regulation of 3D genome structure via lamina-associated domains.
• These investigations will help us understand how SALL4 controls embryonic development and how this protein is de-regulated in developmental disorders and aggressive cancers.
• You will join a collaborative, international group with access to genomics, bioinformatics, proteomics, microscopy and cell culture facilities.

Skills

English (B2)

Genomics literacy

Education

Master degree in genomics / molecular biology

Tools

CRISPR/Cas9 engineering

Job description

About the position

We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.

Desired profile

We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.

In this PhD project, you will exploit state-of-the-art genomics techniques to dissect the molecular function of the transcription factor SALL4 in embryonic stem cells: regulation of transcription via long range enhancer-promoter looping (1), regulation of 3D genome structure via modulation of lamina-associated domains (2). These investigations will help us better understand how SALL4 controls embryonic development, and how this protein is de-regulated in developmental disorders and aggressive cancers. More generally, this work will clarify how transcription factors interact across different genomic scales to regulate cell identity. Additional information regarding the PhD project is available here: https://amethis3.unistra.fr/amethis-client/prd/consulter/offre/1125

You will benefit from a supportive and collaborative work environment to carry out your research. The Institute of Genetics Molecular and Cellular Biology (IGBMC ) includes a diverse and international scientific community and hosts a large range of state-of-the‑art facilities including genomics, bioinformatics, proteomics, microscopy, flow cytometry and cell culture.

Keywords: stem cells, transcription, genome architecture, transcription factors, SALL4, CRISPR/Cas9 engineering, next-generation sequencing

Qualifications and requirements

• Recently obtained Master degree in genomics, molecular biology or other relevant discipline.
• Strong motivation to work in the field of gene regulation and chromatin biology.
• Good handling of standard molecular biology techniques.
• Prior experience in generating or analysing genomics data would be desirable, but not mandatory.
• English language proficiency (B2 or higher).

Application requirements

Required document(s)

Position characteristics

Offer info

Published on 24/07/2026 Contractuel Catégorie A Fixed-term contract - 36 months Full time Experience preferred License not required > Master degree level