PhD position: Structural and Mechanistic Basis of TIP60 Complex Function in Chromatin Regulation and Genome Integrity

Instruct-ERIC; France; Sur place; EUR 23 000 - 28 000; Plein temps

Avantages offerts par ce poste

Access to state-of-the-art cryo-EM

International research team

Competitive salary ~€2,300 gross/month

Résumé du poste

Instruct-ERIC invites outstanding candidates to apply for a PhD position at IGBMC-CERBM in France, investigating the TIP60/EP400 complex in chromatin regulation and genome integrity. The project combines structural biology, biochemistry, and computational drug discovery in a collaborative, international setting.

The position offers access to cutting-edge cryo-EM facilities, a three-year contract with potential extension, and a salary of about €2,300 gross per month.

Qualifications

• Master's degree (or near completion) in a relevant field.
• Background in biochemistry or structural biology preferred.
• Strong communication and collaboration skills.

Responsabilités

• Determine how TIP60-C recognizes nucleosomes to drive H2A.Z exchange.
• Elucidate mechanisms by which TIP60-C promotes DNA damage repair.
• Contribute to project design and interpretation using cryo-EM and computational approaches.

Connaissances

Strong communication skills

Ability to thrive in collaborative,国际?

Formation

Master's degree (or near completion) in biochemistry, chemistry, molecular biology, biomedical sciences, or a related field

Outils

Cryo-EM facilities

Computational drug discovery tools

Description du poste

Jobs in Structural Biology and Related Fields

PhD position: Structural and Mechanistic Basis of TIP60 Complex Function in Chromatin Regulation and Genome Integrity

IGBMC-CERBM, France

Background

The TIP60/EP400 complex (TIP60-C) is a highly conserved 20-subunit chromatin remodeling complex that plays fundamental roles in gene transcription and the maintenance of genome integrity. Through its lysine acetyltransferase (KAT) activity, TIP60-C acetylates histones H4 and H2A to promote chromatin relaxation, while its EP400 ATPase subunit catalyzes the exchange of canonical H2A for the histone variant H2A.Z, thereby regulating chromatin dynamics during transcription and DNA damage repair.

Beyond chromatin regulation, TIP60-C acts as a central signaling hub that coordinates diverse cellular processes, including DNA repair, immune responses, cell cycle progression, apoptosis, autophagy, metabolism, and development. These functions are mediated through the acetylation of both histone and non-histone substrates, which modulates protein activity, stability, and molecular interactions. Dysregulation of TIP60-C is implicated in numerous human diseases, including cancer, neurodegenerative disorders, and viral infections, making it a compelling therapeutic target.

Our laboratory recently solved the high-resolution cryo-EM structure of the endogenous human TIP60 complex (https://www.nature.com/articles/s41586-024-08011-w ), providing an unprecedented view of its molecular architecture. This PhD position builds directly on that breakthrough.

Project Aims

1. Determine how TIP60-C recognizes nucleosomes to drive H2A.Z exchange.

2. Elucidate the molecular mechanisms by which TIP60-C promotes DNA damage repair.

3. Identify and develop novel therapeutic modulators of TIP60-C.

Approach

The project integrates structural biology, biochemistry, cell biology, and computational drug discovery. The successful candidate will employ an interdisciplinary approach, combining single-particle cryo-electron microscopy, structure-based virtual screening, AI-driven de novo peptide and mini-protein design, biochemical characterization, and cellular functional assays.

Candidate Profile

• Highly motivated, with a strong interest in structural biology and biochemistry
• Master's degree (or near completion) in biochemistry, chemistry, molecular biology, biomedical sciences, or a related field.
• Prior experience in protein biochemistry, structural biology, computational biology, or cell biology is a plus, but not required.
• Strong communication skills, intellectual curiosity, and the ability to thrive in a collaborative, international research environment.

What We Offer

• Access to state-of-the-art cryo-EM facilities and cutting-edge computational infrastructure.
• Membership in a dynamic, international team at IGBMC working at the interface of structural biology and structure-based drug leads design.
• A three years’ contract (fourth-year extension possible, subject to competitive funding), salary approximately €2,300 gross/month.

Application

Interested candidates should send a CV, a brief statement of research interests, Grades obtained during the Licence and Master studies, and contact details for two references to [e-mail] before 30 September, 2026.