Lead Principal Scientist, Analytical Development

Placements24; Rustenburg; Hybrid; ZAR 1,200,000 - 1,800,000; Full time

Benefits offered by this job

Bonus program

Comprehensive health insurance

Professional development opportunities

State-of-the-art facilities

Job summary

Placements24 seeks a seasoned Principal Scientist to lead Analytical Development at our Rustenburg R&D hub. You will spearhead method development, validation and transfer for small molecules and biologics, ensuring product quality across development stages.

You will mentor a team of analytical scientists, collaborate with formulation, process development and QC, and stay aligned with regulatory expectations throughout development lifecycles.

Qualifications

• Ph.D. in Analytical Chemistry or Pharmaceutical Sciences required.
• 10+ years of progressive analytical method development and validation experience in pharma/biotech.
• Expertise across HPLC/UPLC, GC-MS/LC-MS, FTIR and UV-Vis with regulatory awareness.

Responsibilities

• Lead development, validation and transfer of analytical methods for small molecules and biologics.
• Oversee characterization of drug substances and products for quality attributes.
• Provide mentorship to analytical scientists and chemists.
• Troubleshoot complex analyses and develop innovative solutions.
• Collaborate with formulation, process development and QC to align activities with regs.

Skills

Analytical method development

Team leadership

Regulatory compliance

Mass spectrometry

HPLC/UPLC

Communication

Education

Ph.D. in Analytical Chemistry or Pharmaceutical Sciences

Tools

HPLC

GC-MS

LC-MS

FTIR

ICP-MS

UV-Vis

Job description

Placements24 seeks a seasoned Principal Scientist to lead Analytical Development at our Rustenburg R&D hub. You will spearhead method development, validation and transfer for small molecules and biologics, ensuring product quality across development stages.

You will mentor a team of analytical scientists, collaborate with formulation, process development and QC, and stay aligned with regulatory expectations throughout development lifecycles.