Bioprocess Engineer - Upington: Scale-Up & GMP Impact

Placements24; Upington; On-site; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Superior medical aid

Retirement savings plans

Life insurance

Paid time off

Professional growth opportunities

Job summary

Placements24 in Upington, Northern Cape, seeks a Bioprocess Engineer to lead development, optimization and scale-up of biopharmaceutical processes for therapeutic proteins. You will design upstream and downstream operations, drive process validation, and ensure regulatory compliance.

The role involves troubleshooting, CAPA, technology transfer to manufacturing sites, and collaboration with R&D, QA, and manufacturing teams to enable data-driven improvements in a state-of-the-art facility.

Qualifications

• Bachelor’s or Master’s degree in Biochemical Engineering, Chemical Engineering, Biotechnology or related field.
• PhD is a plus for senior candidates.

Responsibilities

• Design and optimize upstream (cell culture, microbial) and downstream (purification) bioprocesses.
• Lead scale-up from lab to pilot and commercial manufacturing.
• Develop and execute process validation protocols and regulatory reports (GMP, FDA, EMA).
• Troubleshoot deviations and implement CAPA.
• Collaborate with R&D, QA, Manufacturing, and Analytical Development.
• Identify new technologies and equipment to improve yield and quality.
• Monitor process performance and drive data-driven improvements.
• Support technology transfer to manufacturing sites.

Skills

Bioprocess design

GMP compliance

Scale-up

Tech transfer

Process optimization

Data analysis

Cross-functional collaboration

Problem solving

Project management

Cell culture

Education

Bachelor's in Biochemical Engineering

Bachelor's in Chemical Engineering

Bachelor's in Biotechnology

Master's in Biochemical Engineering

Tools

Process modeling software

Statistical analysis tools

Job description

Placements24 in Upington, Northern Cape, seeks a Bioprocess Engineer to lead development, optimization and scale-up of biopharmaceutical processes for therapeutic proteins. You will design upstream and downstream operations, drive process validation, and ensure regulatory compliance.

The role involves troubleshooting, CAPA, technology transfer to manufacturing sites, and collaboration with R&D, QA, and manufacturing teams to enable data-driven improvements in a state-of-the-art facility.