Biopharma Process Engineer: Scale-Up & Process Development

Placements24; Stellenbosch; On-site; ZAR 900,000 - 1,500,000; Full time

Benefits offered by this job

Performance-based bonuses

Medical aid

Life insurance

Retirement fund

Paid time off

Advanced training programs

Job summary

Placements24, in collaboration with a leading biopharmaceutical company in Stellenbosch, Western Cape, seeks a Biopharmaceutical Process Engineer. You will design, develop, optimize, and scale bioprocesses for biologics, covering upstream cell culture and downstream purification, while ensuring regulatory compliance and robust manufacturing performance.

This on-site role requires at least 5 years in process development or manufacturing within biopharma, hands-on experience with bioprocess unit

Qualifications

• Bachelor's or Master's in Chemical Engineering, Biochemical Engineering, Biotechnology or related field.
• Minimum 5 years in process development, scale-up or manufacturing in biopharma.
• Hands-on with bioprocess unit operations (bioreactors, centrifuges, filtration, chromatography).
• Strong GMP/regulatory understanding and validation principles.
• Experience with process modeling and simulation software is a plus.
• Excellent analytical and problem-solving skills.
• Strong project management and cross-functional collaboration.
• Experience with SPC and DoE is advantageous.

Responsibilities

• Design, develop, and optimize upstream and/or downstream bioprocesses for biologics.
• Conduct development studies from lab to pilot scale and scale-up activities.
• Troubleshoot process issues and implement solutions to ensure quality and yield.
• Develop and implement process validation strategies per regulatory guidelines.
• Prepare and review process descriptions, validation protocols, and regulatory documents.
• Collaborate with manufacturing, QA, and analytical teams for tech transfer.
• Monitor process performance and drive continuous improvement.
• Ensure GMP, safety, and environmental compliance.
• Evaluate and adopt new technologies and equipment.

Skills

GMP knowledge

Process optimization

Cross-functional collaboration

Problem solving

Regulatory understanding

Education

Bachelor's/Master's in Chemical/Biochemical Engineering or Biotechnology

Tools

Process modeling software

SPC/DoE tooling

Job description

Placements24, in collaboration with a leading biopharmaceutical company in Stellenbosch, Western Cape, seeks a Biopharmaceutical Process Engineer. You will design, develop, optimize, and scale bioprocesses for biologics, covering upstream cell culture and downstream purification, while ensuring regulatory compliance and robust manufacturing performance.

This on-site role requires at least 5 years in process development or manufacturing within biopharma, hands-on experience with bioprocess unit