Hybrid Biopharma Process Engineer: Scale-Up & Optimization

Placements24; Randburg; Hybrid; ZAR 1,000,000 - 1,700,000; Full time

Benefits offered by this job

Competitive salary

Health insurance

Retirement plan

Career development

Hybrid work model

Access to biomanufacturing facilities

Stock options

Job summary

Placements24 is seeking a Biopharmaceutical Process Engineer for our client in Randburg, Gauteng. This hybrid role blends on-site hands-on development with remote data analysis and strategic planning.

You will design, develop, and optimize upstream and downstream bioprocesses, scale from lab to commercial, troubleshoot issues, and ensure GMP-compliant operations in state-of-the-art facilities. Collaboration with R&D, Manufacturing, QA, and Project Management will be essential.

Qualifications

• Master's or PhD in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field.
• Min 5 years in biopharmaceutical process development and scale-up.
• Deep knowledge of upstream (cell culture, fermentation) and downstream (chromatography, filtration) bioprocessing.
• Experience with mammalian cell culture, microbial fermentation, or protein purification.
• Familiarity with GMP regulations for biopharmaceutical manufacturing.
• Strong analytical and problem-solving abilities; critical thinking.
• Excellent written and verbal communication; presenting technical information.
• Proficiency with process modeling software (Aspen, gPROMS).
• Ability to work in a hybrid environment (on-site and remote).
• Team player with strong collaboration.

Responsibilities

• Design, develop, and optimize upstream and downstream bioprocesses for manufacturing biopharmaceuticals.
• Scale-up processes from laboratory to pilot plant and commercial scales.
• Troubleshoot and resolve process-related issues to ensure product quality and yield.
• Conduct process characterization studies and define CPPs.
• Develop and implement process control strategies.
• Prepare process descriptions, validation protocols, and regulatory reports.
• Collaborate with R&D, Manufacturing, QA, and Project Management.
• Stay current with emerging technologies and industry best practices.
• Ensure GMP compliance and internal quality standards.
• Perform process simulations and modeling to evaluate performance.

Skills

Biopharmaceutical process development

Scale-up

Cell culture

Analytical thinking

Communication skills

Education

Master's or PhD in Chemical Engineering/Biochemical Engineering/Biotechnology

Tools

Aspen

gPROMS

Job description

Placements24 is seeking a Biopharmaceutical Process Engineer for our client in Randburg, Gauteng. This hybrid role blends on-site hands-on development with remote data analysis and strategic planning.

You will design, develop, and optimize upstream and downstream bioprocesses, scale from lab to commercial, troubleshoot issues, and ensure GMP-compliant operations in state-of-the-art facilities. Collaboration with R&D, Manufacturing, QA, and Project Management will be essential.