Sr. Protein Production Scientist | Purification & Scale-Up

AtlasBase; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

AtlasBase is a fast-growing pioneer in Molecular Computing, seeking a Sr. Research Associate/Scientist to join the Protein Production team in South San Francisco.

You will support the production of recombinant proteins, perform purification workflows on ÄKTA systems, quantify products, and maintain rigorous documentation. The ideal candidate will troubleshoot purification protocols, collaborate across teams, and contribute to scale-up strategies while upholding safety and quality standards in a

Qualifications

• Bachelor’s degree in Chemical Engineering, Biochemistry, Biotechnology or a related scientific discipline.
• Proven experience with a wide range of protein purification techniques, including working with various chromatography resins and instrumentation (e.g., ÄKTA systems).
• Strong attention to detail, ability to work independently in a fast-paced environment, and a proactive team-player mindset.
• Familiarity with laboratory safety protocols and experience maintaining rigorous scientific documentation.
• Prior experience transitioning from laboratory-scale to pilot-level manufacturing and proficiency in column packing procedures is preferred.

Responsibilities

• Execute recombinant protein purification using ÄKTA systems and gravity column chromatography, taking ownership of daily tasks while working under the general guidance of a supervisor.
• Run purification workflows from small-scale runs to large-scale production to ensure consistent yield and purity, collaborating with your supervisor on scale-up strategies.
• Independently troubleshoot routine expression and purification protocols to improve process efficiency, consulting with a supervisor on complex issues or major process changes.
• Perform protein quantification, quality assessment, and characterization to ensure deliverables meet project specifications.
• Maintain detailed inventory records of purified proteins and raw materials; strictly adhere to Standard Operating Procedures (SOPs) and documentation standards for data integrity.
• Maintain clear written and verbal communication with your supervisor and cross-functional teams to ensure alignment on project timelines, and present your scientific findings at team meetings.

Skills

Protein purification techniques

Chromatography

ÄKTA system operation

Education

Bachelor’s degree in Chemical Engineering, Biochemistry, Biotechnology or related field

Tools

ÄKTA systems

Job description

AtlasBase is a fast-growing pioneer in Molecular Computing, seeking a Sr. Research Associate/Scientist to join the Protein Production team in South San Francisco.

You will support the production of recombinant proteins, perform purification workflows on ÄKTA systems, quantify products, and maintain rigorous documentation. The ideal candidate will troubleshoot purification protocols, collaborate across teams, and contribute to scale-up strategies while upholding safety and quality standards in a