Senior Biologics Purification Scientist

R&D Partners

San Rafael (CA)

On-site

USD 69,000 - 86,000

Full time

14 days+

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Benefits offered by this job

Medical insurance

401k plan

Employee Assistance Program

Long-term disability

Weekly payroll

Online timecard approval

Job summary

R&D Partners seeks a Senior Research Associate to advance purification and analytical characterization of biologics in a lab-driven setting in San Rafael, CA. You will independently perform purification of recombinant enzymes, proteins, antibodies, and peptide therapeutics using ÄKTA systems while optimizing workflows across affinity, ion-exchange, SEC, and HIC.

You will also conduct concentration and buffer exchange via TFF/UF/DF, perform analytical assays (SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC,

Qualifications

Bachelor's degree in Biochemistry, Biology, Chemical Engineering, or a related scientific discipline with 4–6 years of relevant industry experience, or Master's degree in a related scientific discipline with 2–4 years of relevant industry experience.
Demonstrated experience purifying recombinant enzymes, proteins, antibodies, or peptide therapeutics.
Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems.
Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV/Vis spectroscopy.
Experience with tangential-flow filtration (TFF) and ultrafiltration/diafiltration (UF/DF) is preferred.
Desired Skills
Experience in protein purification and biologics characterization.
Demonstrated ability to independently plan, execute, troubleshoot, and optimize purification experiments.
Strong analytical and problem-solving skills with excellent attention to detail.
Experience with electronic laboratory notebooks (Benchling or similar) and data analysis software such as GraphPad Prism or JMP.
$69,056-$86,320

Responsibilities

Independently perform purification of recombinant enzymes and other therapeutic biologics, including proteins, antibodies, and peptides, using ÄKTA Pure and ÄKTA Avant chromatography systems.
Execute and optimize purification workflows including Affinity chromatography, Ion exchange chromatography (AEX/CEX), Size-exclusion chromatography (SEC), Hydrophobic interaction chromatography (HIC)
Perform concentration and buffer exchange using tangential-flow filtration (TFF), ultrafiltration/diafiltration (UF/DF), or centrifugal filtration.
Evaluate purification performance and recommend process improvements to enhance yield, purity, and recovery.
Troubleshoot chromatography, filtration, and purification processes with minimal supervision.
Prepare buffers, reagents, and chromatography columns according to established procedures.
Perform routine instrument checks, preventative maintenance, and basic troubleshooting of purification equipment.
Perform analytical assays to assess purity, identity, concentration, and quality of biologics, including: SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, UV/Vis spectrophotometry.
Interpret analytical data to support purification process optimization and project decision-making.
Analyze experimental results using GraphPad Prism, JMP, Microsoft Excel, or similar software.
Communicate experimental findings through technical summaries, presentations, and discussions with cross-functional project teams.
Support analytical method development, qualification, or technology transfer activities as needed.
Maintain accurate and complete electronic and/or paper laboratory notebooks.
Follow established SOPs and document deviations with guidance.