Sr Biologics Purification Scientist & CMC Lead

BioSpace; South San Francisco (CA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Comprehensive benefits package

Job summary

AbbVie’s Biologics CMC Purification Development group in South San Francisco is seeking a senior scientist to design, optimize, and scale purification processes for complex biologics. You will own purification deliverables, guide technology transfer, and ensure robust data-driven decisions in a fast-paced lab environment.

You will collaborate across cross-functional CMC teams, develop strategies for viral clearance, and contribute to regulatory filings while mentoring junior staff and driving

Qualifications

• Experience with downstream bioprocess unit operations such as affinity, ion-exchange, and hydrophobic-interaction chromatography.
• Knowledge of virus filtration and tangential-flow filtration technologies.
• Ability to lead scientific discussions and make data-driven decisions in a fast-paced environment.
• Experience in process-development reports, tech-transfer packages, and regulatory documentation.

Responsibilities

• Develop, optimize, characterize, and scale purification processes for monoclonal antibodies, multispecifics, and related biologics across development stages.
• Lead technology transfer to GMP manufacturing sites and support facility readiness.
• Develop viral clearance strategies and oversee studies with contract laboratories.
• Mentor junior scientists and contribute to cross-functional team strategy.
• Write publications, regulatory filings, and transfer technical knowledge efficiently.

Skills

Downstream bioprocess

Purification process development

Data analysis

Regulatory/CMC knowledge

Cross-functional collaboration

Mentoring

Education

Bachelor’s in Chemical Engineering / Biochemistry / Chemistry or related field

Master’s or PhD preferred

Tools

JMP

Python

R

AKTA chromatography systems

Tecan / Hamilton liquid handling robots

Job description

AbbVie’s Biologics CMC Purification Development group in South San Francisco is seeking a senior scientist to design, optimize, and scale purification processes for complex biologics. You will own purification deliverables, guide technology transfer, and ensure robust data-driven decisions in a fast-paced lab environment.

You will collaborate across cross-functional CMC teams, develop strategies for viral clearance, and contribute to regulatory filings while mentoring junior staff and driving