Biologics Purification Scientist, Downstream

AbbVie Inc.; North Chicago (IL); In loco; USD 110.000 - 140.000; Tempo pieno

Descrizione del lavoro

AbbVie Inc. in North Chicago, IL, seeks a Scientist I/II in Biologics Purification to lead end-to-end purification campaigns for multi-specific antibody biologics. You will design downstream strategies, apply analytical tools, and work with cross-functional teams to accelerate therapeutic candidates from bench to discovery.

The role emphasizes chromatographic purification, data-driven decisions, and continuous process improvement within a collaborative biologics discovery science group.

Competenze

• Demonstrated expertise in preparative-scale column chromatography techniques (i.e. affinity, IEX, HIC, multimodal) for antibody-based biologics purification
• Hands-on experience operating AKTA chromatography systems and Unicorn software
• Strong foundation in analytical characterization techniques, including HPLC, gel electrophoresis, ELISA, mass spectrometry, and related methods
• Knowledge of biologics manufacturing or process development is a plus
• Solid understanding of protein structure, molecular attributes and post-translational modifications impacting biologic quality and performance
• Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts to diverse audiences
• Track record of scientific curiosity, innovation, and continuous learning
• Collaborative mindset with a passion for teamwork, scientific rigor, and delivering impactful solutions

Mansioni

• Lead end-to-end purification campaigns at production-based scales for delivery of high-quality multi-specific antibody biologics to support critical research efforts and program decisions
• Design and optimize downstream purification strategies using advanced chromatography techniques to remove process impurities, mitigate product liabilities, and achieve target quality attributes
• Apply deep analytical expertise to characterize molecules, process intermediates, impurities, and final drug candidates, enabling data-driven process decisions
• Drive scientific innovation and continuous process improvement by identifying and implementing novel approaches that enhance downstream biologics development workflows
• Partner across multidisciplinary teams, translating process insights into functional results to accelerate the advancement of therapeutic candidates
• Communicate scientific findings with clarity and influence, presenting technical information to diverse audiences to support project progression and knowledge sharing

Conoscenze

Column chromatography

AKTA Unicorn

Analytical techniques

Biologics manufacturing

Protein science

Formazione

BS/MS in Biochemistry/Biophysics/Biomedical/Chemical Engineering

Strumenti

Unicorn software

Descrizione del lavoro

AbbVie Inc. in North Chicago, IL, seeks a Scientist I/II in Biologics Purification to lead end-to-end purification campaigns for multi-specific antibody biologics. You will design downstream strategies, apply analytical tools, and work with cross-functional teams to accelerate therapeutic candidates from bench to discovery.

The role emphasizes chromatographic purification, data-driven decisions, and continuous process improvement within a collaborative biologics discovery science group.