Biologics Purification Scientist - Multi-Specific Antibodies

BioSpace; North Chicago (IL); On-site; USD 110,000 - 170,000; Full time

Job summary

AbbVie’s Biologics Discovery Sciences group seeks a scientist specializing in Biologics Purification to drive high-purity multi-specific antibody biologics for in vitro and in vivo studies. You will lead end-to-end purification campaigns, optimize downstream strategies, and collaborate across teams to enable data-driven decisions and project progression.

The role emphasizes analytical characterization, continuous process improvement, and clear communication of complex science to diverse

Qualifications

• BS or MS in Biochemistry, Biophysics, Biomedical, Chemical Engineering, or a related field, with typically 5-7 years (BS) or 2-5 years (MS) of experience
• Demonstrated expertise in preparative-scale column chromatography techniques (i.e. affinity, IEX, HIC, multimodal) for antibody-based biologics purification
• Hands-on experience operating AKTA chromatography systems and Unicorn software
• Strong foundation in analytical characterization techniques, including HPLC, gel electrophoresis, ELISA, mass spectrometry, and related methods
• Knowledge of biologics manufacturing or process development is a plus
• Solid understanding of protein structure, molecular attributes and post-translational modifications impacting biologic quality and performance
• Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts to diverse audiences
• Track record of scientific curiosity, innovation, and continuous learning
• Collaborative mindset with a passion for teamwork, scientific rigor, and delivering impactful solutions

Responsibilities

• Lead end-to-end purification campaigns at production-based scales for delivery of high-quality multi-specific antibody biologics to support critical research efforts and program decisions
• Design and optimize downstream purification strategies using advanced chromatography techniques to remove process impurities, mitigate product liabilities, and achieve target quality attributes
• Apply deep analytical expertise to characterize molecules, process intermediates, impurities, and final drug candidates, enabling data-driven process decisions
• Drive scientific innovation and continuous process improvement by identifying and implementing novel approaches that enhance downstream biologics development workflows
• Partner across multidisciplinary teams, translating process insights into functional results to accelerate the advancement of therapeutic candidates
• Communicate scientific findings with clarity and influence, presenting technical information to diverse audiences to support project progression and knowledge sharing

Skills

Affinity chromatography

IEX chromatography

HIC chromatography

Multimodal chromatography

AKTA

Unicorn software

Analytical methods

Mass spectrometry

ELISA

Protein attributes

Education

Biochemistry degree

Biophysics degree

Biomedical Eng degree

Chemical Eng degree

Tools

AKTA

Unicorn software

Job description

AbbVie’s Biologics Discovery Sciences group seeks a scientist specializing in Biologics Purification to drive high-purity multi-specific antibody biologics for in vitro and in vivo studies. You will lead end-to-end purification campaigns, optimize downstream strategies, and collaborate across teams to enable data-driven decisions and project progression.

The role emphasizes analytical characterization, continuous process improvement, and clear communication of complex science to diverse