Spatial Biology Scientist: High-Plex Histology

Magnit; Ridgefield (CT); In loco; USD 90.000 - 130.000; Tempo pieno

Descrizione del lavoro

Boehringer Ingelheim's Oncology Research department in Ridgefield, CT is seeking a Histotechnologist / Spatial Biology Specialist to advance spatial biology capabilities for preclinical biomarker discovery. The role combines histology, imaging, and data analysis to develop high-plex tissue-based assays, validate panels, and integrate protein/RNA spatial data with computational workflows.

Ideal candidates will have experience with multiplex imaging and quantitative microscopy, and a collaborative

Competenze

• Experience with high-plex/multiplex protein imaging and antibody panel development.
• Experience with spatial transcriptomics or related spatial gene-expression technologies.
• Experience with quantitative microscopy or high-content tissue imaging.
• Experience with image analysis, such as tissue annotation, cell segmentation, phenotyping, spatial measurements, or quantitative biomarker analysis.

Mansioni

• Develop, optimize, and execute high-plex tissue-based assays, including multiplex immunofluorescence and other spatial protein profiling approaches in human and mouse tissues.
• Design and optimize multiplex antibody panels, including antibody selection, staining conditions, controls, panel compatibility, tissue-specific optimization, and assay performance.
• Support the establishment and application of spatial transcriptomics and emerging spatial profiling technologies, including assay and data QC.
• Develop integrated workflows spanning tissue preparation, staining, imaging, spatial profiling, and quantitative analysis, troubleshooting assays to improve robustness, reproducibility, and data quality.
• Support acquisition and analysis of whole-slide, multiplex, and spatial imaging datasets, including tissue annotation, cell segmentation, phenotyping, spatial quantification, and visualization.
• Collaborate with computational scientists and project teams to integrate spatial protein, RNA, imaging, and histopathology data.

Conoscenze

High-plex imaging

Histology

Image analysis

R

Python

Tissue processing

Formazione

Bachelor’s or Master’s degree

Strumenti

IHC/IF instrumentation

Slide scanners

H&E staining equipment

Descrizione del lavoro

Boehringer Ingelheim's Oncology Research department in Ridgefield, CT is seeking a Histotechnologist / Spatial Biology Specialist to advance spatial biology capabilities for preclinical biomarker discovery. The role combines histology, imaging, and data analysis to develop high-plex tissue-based assays, validate panels, and integrate protein/RNA spatial data with computational workflows.

Ideal candidates will have experience with multiplex imaging and quantitative microscopy, and a collaborative