Histotechnician: Spatial Biology & High-Plex Imaging

System One, Inc.; Ridgefield (CT); On-site; USD 39,000 - 52,000; Full time

Job summary

System One, Inc. in Ridgefield, CT is seeking a Histotechnician / Spatial Biology Specialist to support the Discovery Research team, expanding capabilities for preclinical biomarker discovery.

You will develop and optimize high-plex tissue-based assays, perform core histology workflows, and contribute to quantitative imaging and data quality.

This onsite contract role requires 40 hours weekly and close collaboration with computational and translational research teams.

Qualifications

• Bachelor's or Master's degree in Biology, Histotechnology, Pathology, Biomedical Sciences, or a related discipline.

Responsibilities

• Develop, optimize, and execute high-plex tissue-based assays, including multiplex immunofluorescence and other spatial protein profiling approaches in human and mouse tissues.
• Design and optimize multiplex antibody panels, including antibody selection, staining conditions, controls, panel compatibility, tissue-specific optimization, and assay performance.
• Support the establishment and application of spatial transcriptomics and emerging spatial profiling technologies, including assay and data QC.
• Develop integrated workflows spanning tissue preparation, staining, imaging, spatial profiling, and quantitative analysis, troubleshooting assays to improve robustness, reproducibility, and data quality.
• Collaborate with computational scientists and project teams to integrate spatial protein, RNA, imaging, and histopathology data.

Skills

High-plex imaging

Spatial transcriptomics

Quantitative microscopy

Image analysis

R & Python

Education

Bachelor's or Master's degree in Biology/Histotechnology or related discipline

Tools

R

Python

Job description

System One, Inc. in Ridgefield, CT is seeking a Histotechnician / Spatial Biology Specialist to support the Discovery Research team, expanding capabilities for preclinical biomarker discovery.

You will develop and optimize high-plex tissue-based assays, perform core histology workflows, and contribute to quantitative imaging and data quality.

This onsite contract role requires 40 hours weekly and close collaboration with computational and translational research teams.