Senior Scientist, Therapeutic Antibody Characterization

Future Ventures; Berkeley (CA); Hybrid; USD 130,000 - 180,000; Full time

Benefits offered by this job

Competitive benefits package

Stock-based long-term incentives

Winter shutdown holiday package

Remote and hybrid work options

Job summary

Prellis Biologics is seeking a Senior Scientist to lead analytical characterization of therapeutic antibodies and related biologics. You will apply biochemical and biophysical methods to assess quality, developability, stability, and structure, collaborating with Discovery, Protein Engineering, and CMC teams.

Responsibilities include designing and optimizing assays (Tm, Tagg, AC-SINS, HIC, cIEF, aSEC, BVP), generating robust data, and delivering clear technical reports for decision-making in

Qualifications

• Ph.D. or M.S. in Biochemistry, Chemistry, Molecular Biology, Pharmaceutical Sciences, or related discipline.
• Minimum of 3 years of industry experience in analytical characterization of therapeutic antibodies, bispecific antibodies, Fc-fusion proteins, or other biologics.
• Strong hands-on experience with protein characterization techniques including Tm, Tagg (Uncle), AC-SINS, HIC, cIEF, aSEC, and BVP.

Responsibilities

• Perform comprehensive analytical characterization of therapeutic monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, and related biologics.
• Conduct biophysical and developability assessments using techniques such as Tm, Tagg (Uncle), AC-SINS, HIC, cIEF, aSEC, and BVP assays.
• Generate, analyze, and interpret analytical data to support lead candidate selection, formulation development, stability studies, and analytical comparability assessments.
• Design, execute, troubleshoot, and optimize analytical methods to support therapeutic protein characterization.
• Prepare clear, accurate, and well-organized technical reports and present experimental findings to cross-functional project teams.
• Collaborate closely with scientists in Antibody Discovery & Protein Engineering.
• Maintain accurate laboratory documentation and ensure compliance with laboratory safety and quality standards.

Skills

Tm

Tagg (Uncle)

AC-SINS

HIC

cIEF

aSEC

BVP

Education

PhD or MS in Biochemistry/related

Tools

LC-MS

Job description

Prellis Biologics is seeking a Senior Scientist to lead analytical characterization of therapeutic antibodies and related biologics. You will apply biochemical and biophysical methods to assess quality, developability, stability, and structure, collaborating with Discovery, Protein Engineering, and CMC teams.

Responsibilities include designing and optimizing assays (Tm, Tagg, AC-SINS, HIC, cIEF, aSEC, BVP), generating robust data, and delivering clear technical reports for decision-making in