Senior Scientist, Functional Assay Development

Prellis Biologics, Inc.; Berkeley (CA); On-site; USD 141,000 - 216,000; Full time

Benefits offered by this job

Stock-based long-term incentives

Flexible work models: remote andHybrid

Health and welfare plans

Holiday package with winter shutdown

Job summary

Prellis Biologics, Berkeley, CA, is seeking a Senior Scientist or Principal Scientist to lead functional assay development for antibody discovery. This hands-on, laboratory role requires bench work on site and cross-functional collaboration across Discovery, Protein Sciences, and Data Science.

You will design, optimize, and validate cell-based assays (HTRF, reporter, on-cell binding), drive cardiometabolic assay strategy, and guide the team from concept to routine screening while mentoring

Qualifications

• Ph.D. in Cell Biology, Biochemistry, Molecular Biology, Pharmacology, or related field with equivalent industry experience – Senior Scientist: 3–5 years, Principal Scientist: 5+ years
• Hands-on experience developing cell-based functional assays from scratch, not solely executing established protocols
• Strong hands-on experience with mammalian cell lines, including stable cell line generation
• Familiarity with high-content imaging platforms is a plus
• Demonstrated ability to work independently and collaboratively in a fast-paced, cross-functional environment
• Excellent problem-solving, organizational, and communication skills
• Mentorship of junior researchers; clear scientific communication

Responsibilities

• Design, optimize, and validate cell-based functional assays from conception through tech transfer to routine screening use, supporting cardiometabolic programs as well as I&I and IO pipelines
• Apply domain expertise in cardiometabolic signaling pathways to translate target biology into assay designs
• Run functional assays against the standing screening queue, ensuring throughput and data quality
• Coordinate across discovery pipeline to ensure assay requirements align with program priorities
• Evaluate and implement miniaturization and automation to scale capacity
• Prepare clear, concise reports summarizing experimental results and assay strategy recommendations

Skills

Cell-based assay development

Cross-functional collaboration

Mentorship

Independent & fast-paced work

Excellent communication

Education

Ph.D. in Cell Biology, Biochemistry, Molecular Biology, Pharmacology, or related field

Ph.D. or equivalent industry experience

Tools

High-content imaging platforms

Job description

Prellis Biologics, Berkeley, CA, is seeking a Senior Scientist or Principal Scientist to lead functional assay development for antibody discovery. This hands-on, laboratory role requires bench work on site and cross-functional collaboration across Discovery, Protein Sciences, and Data Science.

You will design, optimize, and validate cell-based assays (HTRF, reporter, on-cell binding), drive cardiometabolic assay strategy, and guide the team from concept to routine screening while mentoring