Senior Scientist: Next-Gen Antibody Characterization

BioSpace

Berkeley (CA)

Hybrid

USD 120,000 - 180,000

Full time

3 days ago

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Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k)

Remote/Hybrid work

Job summary

Prellis Biologics, based in Berkeley, CA, seeks a Senior Scientist to lead analytical characterization of monoclonal and bispecific antibodies, Fc-fusion proteins, and other biologics to support candidate selection and preclinical development. You will apply biochemical and biophysical techniques to assess quality and developability while partnering with discovery and engineering teams.

Ideal candidates have strong hands-on experience with protein characterization (Tm, Tagg, AC-SINS, HIC, cIEF,

Qualifications

Ph.D. or MS in Biochemistry, Chemistry, Molecular Biology, Pharmaceutical Sciences, or a related discipline.
Minimum of 3 years of industry experience in the analytical characterization of therapeutic antibodies, bispecific antibodies, Fc-fusion proteins, or other biologics.
Strong hands-on experience with protein characterization techniques, including Tm, Tagg, AC-SINS, HIC, cIEF, analytical SEC (aSEC), BVP, and related biochemical and biophysical assays.
Demonstrated ability to independently design experiments, analyze data, solve technical challenges, and communicate scientific findings effectively.
Excellent organizational, interpersonal, and written communication skills, with the ability to work effectively in a collaborative, multidisciplinary environment.

Responsibilities

Perform comprehensive analytical characterization of therapeutic monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, and related biologics.
Conduct biophysical and developability assessments using techniques including Tm, Tagg, AC-SINS, HIC, cIEF, analytical SEC (aSEC), and BVP assays.
Generate, analyze, and interpret analytical data to support lead candidate selection, formulation development, stability studies, and analytical comparability assessments.
Design, execute, troubleshoot, and optimize analytical methods to support therapeutic protein characterization.
Prepare clear, accurate, and well-organized technical reports and present experimental findings to cross-functional project teams.
Collaborate closely with scientists in Antibody Discovery & Protein Engineering
Maintain accurate laboratory documentation and ensure compliance with laboratory safety and quality standards.