Senior Scientist, Target Biology & Discovery – Hematology

Novartis AG; Cambridge (MA); On-site; USD 94,000 - 174,000; Full time

Job summary

Novartis Biomedical Research in Cambridge, MA, is seeking a highly motivated laboratory scientist to join the Target Biology and Discovery group. You will identify targets, validate them using CRISPR and other methods, and develop cellular assays to support early drug discovery in hematologic cancers.

You will work with disease-relevant models, including primary samples and cancer cell lines, in a collaborative, matrixed environment.

Qualifications

• Degree in biology or related field with 3–5 years of lab experience.
• Hands-on molecular and cellular biology experience required.
• Experience creating robust cellular assays and protocols.
• Proficiency in mammalian cell culture and analysis methods.
• Ability to plan experiments and interpret results independently.

Responsibilities

• Identify key drug-discovery questions and design experiments.
• Support target identification/validation in hematologic malignancies.
• Develop and optimize cellular assays for early drug development.
• Work with disease-relevant models including patient samples.
• Collaborate in a matrixed environment to shape project plans.
• Communicate results and recommendations to teams.

Skills

Mammalian cell culture

Molecular biology methods

Cellular assay development

CRISPR-based perturbation

Experimental design

Data interpretation

Scientific communication

Collaboration

Education

Bachelor's or Master’s degree in biology

Tools

Cloning

qPCR

Western blotting

Flow cytometry

Job description

Novartis Biomedical Research in Cambridge, MA, is seeking a highly motivated laboratory scientist to join the Target Biology and Discovery group. You will identify targets, validate them using CRISPR and other methods, and develop cellular assays to support early drug discovery in hematologic cancers.

You will work with disease-relevant models, including primary samples and cancer cell lines, in a collaborative, matrixed environment.