Senior Scientist, T-Cell Engagers & Bispecifics

Jobless; San Jose (CA); On-site; USD 140,000 - 200,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

FSA

STD/LTD

Life Insurance

401(k) Plan

Paid Time Off

Sick Days

Holidays

Employee Referral Bonus Program

Annual Bonus Program

Stock options

Job summary

Oxford Biotherapeutics is seeking a Senior Scientist to advance T-cell engagers from discovery through IND. You will lead in vitro functional studies, develop multiparameter T-cell assays, and build data packages for decision‑making.

The role combines hands-on experimentation with scientific leadership and cross‑functional collaboration. You will collaborate with internal teams and external partners to optimize TCE formats, improve tumor killing efficacy, and communicate findings clearly.

Qualifications

• PhD with 4–6 years of post‑PhD experience or MS with 8–12 years of industry experience.
• Hands‑on experience with T‑cell engagers and/or bispecific antibody formats.
• Strong experience with core immunology techniques including PBMC isolation, T‑cell assays, and flow cytometry.
• Ability to design, analyze, and interpret complex datasets and translate results into actionable conclusions.
• Excellent written and verbal communication for cross‑functional teams and external collaborators.
• Team player with the ability to lead and influence within a discovery research program.

Responsibilities

• Design, execute, and lead in vitro functional studies for target discovery and preclinical development of T‑cell engagers.
• Develop and optimize T‑cell functional assays to inform potency, selectivity, and safety.
• Design and run co‑culture assays to evaluate tumor cell killing by T‑cell engagers.
• Perform primary human T‑cell assays including activation, cytokine release, and proliferation.
• Build data packages and communicate scientific conclusions to project teams and collaborators.
• Collaborate across teams and with CROs to deliver high‑quality data on a timely basis.

Skills

T‑cell engagers

Flow cytometry

Cytokine assays

Primary T cells

Data interpretation

Scientific leadership

Education

PhD

MS degree

Tools

ELISA

AlphaLISA

Luminex

Job description

Oxford Biotherapeutics is seeking a Senior Scientist to advance T-cell engagers from discovery through IND. You will lead in vitro functional studies, develop multiparameter T-cell assays, and build data packages for decision‑making.

The role combines hands-on experimentation with scientific leadership and cross‑functional collaboration. You will collaborate with internal teams and external partners to optimize TCE formats, improve tumor killing efficacy, and communicate findings clearly.