Scientist (Multi-specific Antibody Development)

Integratedcooling; San Jose (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) plan

Paid time off

Sick days

Holidays

Employee referral bonus

Annual bonus

Stock options

Job summary

Oxford Biotherapeutics is a clinical-stage biotechnology company advancing multi-specific TCEs and antibody therapeutics for cancer. The Scientist will lead discovery efforts, design multi-specific antibodies, execute in vitro assays, and communicate data-driven conclusions to cross-functional teams.

The role emphasizes hands-on experimentation, data generation, and collaboration to advance IND-enabling studies, with opportunities for leadership and cross-functional impact in early discovery and

Qualifications

• Experience supporting discovery and optimization of T-cell engagers or bispecific antibodies.
• Experience with stable cell line generation (Lentiviral transduction, CRISPR KO).
• Experience with antibody binding assays (ELISA, flow cytometry).
• Experience with immune cell co-culture cytotoxicity assays (live readouts).
• Multiparameter flow cytometry and panel design.
• T-cell activation assays and cytokine profiling.
• Ability to design, analyse, and interpret complex datasets and translate results into clear scientific conclusions.

Responsibilities

• Contribute to design of multi-specific antibodies and oversee production/purification.
• Design, execute, and lead in vitro functional studies for target combinations and preclinical development.
• Develop, optimize, and perform functional assays to inform potency, selectivity, and safety.
• Generate and interpret datasets with rigorous data quality.
• Build data packages and communicate conclusions to teams.

Skills

T-cell engagers

Antibody binding assays

Flow cytometry

Co-culture cytotoxicity

Multiparameter flow

Cytotoxicity assays

Data interpretation

Scientific communication

Team collaboration

Education

PhD in relevant field

MS in immunology/biologics

Tools

Lentiviral transduction

CRISPR knockout

Job description

Oxford Biotherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer. OBT’s OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumors. OGAP is used to identify novel, highly tumor specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets. Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development. Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and Zymeworks.

Job Description

We areseekinga highly motivated and intellectually curious Scientist to support the discovery and optimization of multi-specific TCEs. The successful candidate will generate high-quality, decision-enabling data across early discovery through IND-enabling studies. This role combines deep hands-on experimental expertise with scientific leadership, assay innovation, and cross-functional collaboration to advance OBT’s multi-specific pipeline.

This role will be filled at theScientist level.

Responsibilities will include, but are not limited to, the following:

Scientific Leadership & Program Execution

• Contribute to the design of multi-specific antibodies and oversee their production/purification.

• Design, execute, and lead in vitro functional studies supporting the validation of target combinations, lead selection, and preclinical development of multi-specific TCEs.

• Develop,optimize, andperformfunctional assays to inform potency, selectivity, and safety.(e.g., cytotoxicity, cytokine release, reporter assays).

• Generate and interpret complex datasets with a strong emphasis on scientific rigor, reproducibility, and data quality.

• Builddecision-focuseddata packages and communicate clear scientific conclusions and recommendations to project teams and management.

Assay Development & Technical Expertise

• Familiarity with diverse antibody platforms and strategies for the design and production of multi-specific antibodies

• Optimize and characterize binding properties of multi-specific antibodies (ELISA, flow cytometry, cell bridging assays)

• Develop and execute multiparameter flow cytometry to assess T-cell activation

• Design and performreal-timecytotoxicity assays (e.g., IncuCyte, eSight) and other functional readouts relevant to T‑cell engager activity (e.g., reporter assays).

• Design and generate engineered cell systems, including overexpression and CRISPR-based knockout models.

• Isolation and maintenance of primary immune cell populations (e.g., PBMCs, T-cells)

Collaboration &Cross‑FunctionalEngagement

• Collaborate closelyacrossteams toevaluateandoptimizemulti-specific TCEs.

• Coordinate with CROs to deliver high quality, timely data.

• Proactivelyidentifyproject risks, propose mitigation strategies, and communicate progress and challenges clearly to stakeholders.

Innovation & External Awareness

• Monitor the scientific literature and competitive landscape relevant tomulti-specific TCEs and emerging immuneredirecting modalities.

• Propose innovative experimental approaches to accelerate early-stagediscovery.

• Monitor the scientific literature and competitive landscaperelevant to OGAP-selected targets.

Team Leadership & Culture

• Foster a culture of scientific rigor, learning, transparency, accountability, and inclusion.

• Contribute scientific expertise and innovative thinking to project teams.

Compliance & Documentation

• Adhere to OBT’s Quality Management System (QMS), including SOPs, documentation standards, electronic lab notebooks, and required training.

• Support audit readiness and contribute to continuous improvement of laboratory systems and workflows.

Please note the roles and responsibilities for the position include but are not limited to the above

Required Qualifications and Skills:

• Experience supporting the discovery, characterization, and optimization of T-cell engagers, bispecific antibodies or other immune redirecting biologics.

• Experience with stable cell line generation (Lentiviral transduction, CRISPR KO)

• Expertise with antibody binding assays (ELISA, flow cytometry)

• Immune cell co-culture cytotoxicity assays with live readouts (Incucyte, eSight)

• Multiparameter flow cytometry and panel design

• T-cell activation assays (Reporter assays, immune-profiling and cytokine secretion)

• Demonstrated ability to design, analyse, and interpret complex datasets and translate results into clear scientific conclusions.

• Strong written and verbal communication skills, with the ability to present data to multidisciplinary audiences.

• Combines a humble, team‑oriented mindset with the ability to form and voice clear, independent viewpoints.

Scientist Level

• PhD with 1–3 years of relevant post‑PhD experience, or

• MS with 5–7 years of relevant industry experience in immunology, cell biology, or biologics discovery

Preferred Qualifications and Skills:

• Experience with affinity tuning/detuning and epitope selection to achieve logic-gated targeting

• Hands on experience with complex co-culture systems (e.g., organoids)

• Experience managing cross-functional/CRO studies related to in vivo cancer models

• Experience contributing to biologics discovery programs from early discovery through lead optimization and/or preclinical development.

• Track record of scientific impact demonstrated through publications, patents, presentations, or program advancement.

One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.

BenefitsOffered:

• Medical,dentalandvisioninsuranceforemployeeanddependents

• FSA(FlexibleSpendingAccount)

• STD,LTD,BasicLifeandAD&DInsurance,SupplementalLife

• 401(k)Plan

• 120hoursofPaidTimeOff

• 5sickdaysperyear

• 11holidays

• EmployeeReferralBonusProgram

• Annualbonusprogram

• Newhirestockoptions

EqualOpportunitiesStatement

OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment. One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits