Scientist, Multi-Specific TCE Discovery & Antibodies

Integratedcooling; San Jose (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) plan

Paid time off

Sick days

Holidays

Employee referral bonus

Annual bonus

Stock options

Job summary

Oxford Biotherapeutics is a clinical-stage biotechnology company advancing multi-specific TCEs and antibody therapeutics for cancer. The Scientist will lead discovery efforts, design multi-specific antibodies, execute in vitro assays, and communicate data-driven conclusions to cross-functional teams.

The role emphasizes hands-on experimentation, data generation, and collaboration to advance IND-enabling studies, with opportunities for leadership and cross-functional impact in early discovery and

Qualifications

• Experience supporting discovery and optimization of T-cell engagers or bispecific antibodies.
• Experience with stable cell line generation (Lentiviral transduction, CRISPR KO).
• Experience with antibody binding assays (ELISA, flow cytometry).
• Experience with immune cell co-culture cytotoxicity assays (live readouts).
• Multiparameter flow cytometry and panel design.
• T-cell activation assays and cytokine profiling.
• Ability to design, analyse, and interpret complex datasets and translate results into clear scientific conclusions.

Responsibilities

• Contribute to design of multi-specific antibodies and oversee production/purification.
• Design, execute, and lead in vitro functional studies for target combinations and preclinical development.
• Develop, optimize, and perform functional assays to inform potency, selectivity, and safety.
• Generate and interpret datasets with rigorous data quality.
• Build data packages and communicate conclusions to teams.

Skills

T-cell engagers

Antibody binding assays

Flow cytometry

Co-culture cytotoxicity

Multiparameter flow

Cytotoxicity assays

Data interpretation

Scientific communication

Team collaboration

Education

PhD in relevant field

MS in immunology/biologics

Tools

Lentiviral transduction

CRISPR knockout

Job description

Oxford Biotherapeutics is a clinical-stage biotechnology company advancing multi-specific TCEs and antibody therapeutics for cancer. The Scientist will lead discovery efforts, design multi-specific antibodies, execute in vitro assays, and communicate data-driven conclusions to cross-functional teams.

The role emphasizes hands-on experimentation, data generation, and collaboration to advance IND-enabling studies, with opportunities for leadership and cross-functional impact in early discovery and