Senior Immunology Scientist - T Cell Engagers

Marengo Therapeutics; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Free parking

Health coverage (medical)

401K (no matching)

Vacation and holidays

Parental leave

Job summary

Marengo Therapeutics, located in Cambridge, MA, is seeking a Senior Scientist with deep in vitro immunology expertise to design and lead cell-based assays using primary human, NHP, and rodent immune cells. You will drive data to shape program strategy and serve as an SME on cross-functional program teams.

You will lead TDCC and multi-parameter flow cytometry studies, mentor junior staff, and contribute to target discovery and validation for next-generation T cell engagers and immune-modulating

Qualifications

• PhD in Immunology, Cell Biology, or related field with 4+ years of experience, or MS with 8+ years immunology experience.
• Demonstrated experience executing immunological assays with primary immune cells.
• Hands-on experience with T cell functional assays, including activation, proliferation, cytokine production, and cytotoxicity readouts.
• Strong data analysis and interpretation skills, with the ability to translate complex datasets into clear conclusions.
• Expertise with multi-parameter flow cytometry.

Responsibilities

• Independently design, optimize, and execute in vitro and ex vivo cellular assays leveraging primary human, murine, and NHP immune cells to evaluate target engagement, activation, cytotoxicity, and mechanism of action.
• Build and run T cell engager–specific pharmacology assays — including TDCC and tumor cell co-culture killing across various densities — to define potency and selectivity.
• Characterize Vβ-selective T cell activation, expansion, and memory/exhaustion phenotypes to connect design to mechanism of action.
• Apply advanced flow cytometry and immunoassays (ELISA, MSD) to characterize immune cell function.
• Mentor junior scientists on assay execution, data interpretation, and lab practices.
• Support in vivo study activities in collaboration with the broader team.

Skills

Immunology

Data analysis

Flow cytometry

Cross-functional collaboration

Scientific communication

Education

PhD in Immunology or related

MS with 8+ years immunology

Tools

FlowJo

OMIQ

GraphPad Prism

ELISA

MSD

Job description

Marengo Therapeutics, located in Cambridge, MA, is seeking a Senior Scientist with deep in vitro immunology expertise to design and lead cell-based assays using primary human, NHP, and rodent immune cells. You will drive data to shape program strategy and serve as an SME on cross-functional program teams.

You will lead TDCC and multi-parameter flow cytometry studies, mentor junior staff, and contribute to target discovery and validation for next-generation T cell engagers and immune-modulating